article priority journal nonhuman controlled study animal cell unclassified drug rat aldosterone Rats Air-water interface Animals enzyme activity Adsorption HSP90 Heat-Shock Proteins heat shock protein 90 mouse Tacrolimus Binding Proteins animal tissue protein expression Aldosterone male steroidogenesis Active Transport, Cell Nucleus Animal Animalia Interactions Kinetics Polysaccharide Support, Non-U.S. Gov't messenger RNA