Article Glycoproteins Neuraminidase Structure-Activity Relationship Trans-sialidase Trypanosoma cruzi antagonists and inhibitors chemistry controlled study enzyme inhibition glycoprotein nonhuman sialidase sialidase inhibitor sialylation structure activity relation trans-sialidase 2 [2 carboxy 1 (2 nitrophenyl)ethyl] 1,3 dioxoisoindoline 5 carboxylic acid 2 [2 carboxy 1 (4 ethylphenyl)ethyl] 1,3 dioxoisoindoline 5 carboxylic acid 2 [2 carboxy 1 (4 hydroxyphenyl)ethyl] 1,3 dioxoisoindoline 5 carboxylic acid 2 [2 carboxy 1 (4 methoxyphenyl)ethyl] 1,3 dioxoisoindoline 5 carboxylic acid 2 [2 carboxy 1 (4 nitrophenyl)ethyl] 1,3 dioxoisoindoline 5 carboxylic acid 2 [2 carboxy 1 (4 tolyl)ethyl] 1,3 dioxoisoindoline 5 carboxylic acid 3 (1,3 dioxoisoindolin 2 yl) 3 (4 ethylphenyl)propanoic acid 3 (1,3 dioxoisoindolin 2 yl) 3 (4 hydroxyphenyl)propanoic acid 3 (1,3 dioxoisoindolin 2 yl) 3 (4 methoxyphenyl)propanoic acid 3 (1,3 dioxoisoindolin 2 yl) 3 (4 nitrophenyl)propanoic acid 3 (1,3 dioxoisoindolin 2 yl) 3 (4 tolyl)propanoic acid 3 (4 ethylphenyl) 3 (5 methyl 1,3 dioxoisoindolin 2 yl)propanoic acid 3 (4 hydroxyphenyl) 3 (5 methyl 1,3 dioxoisoindolin 2 yl)propanoic acid