Protein Stability and Dynamics Modulation: The Case of Human Frataxin

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Frataxin (FXN) is an α/β protein that plays an essential role in iron homeostasis. Apparently, the function of human FXN (hFXN) depends on the cooperative formation of crucial interactions between helix α1, helix α2, and the C-terminal region (CTR) of the protein. In this work we quantitatively expl...

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Detalles Bibliográficos
Autores principales: Roman, E.A., Faraj, S.E., Gallo, M., Salvay, A.G., Ferreiro, D.U., Santos, J.
Formato: JOUR
Materias:
frataxin
alpha helix
article
carboxy terminal sequence
circular dichroism
fluorescence analysis
hydrodynamics
nuclear magnetic resonance spectroscopy
protein folding
protein function
protein secondary structure
protein stability
protein tertiary structure
protein unfolding
quantitative analysis
structure analysis
Circular Dichroism
Homeostasis
Humans
Hydrodynamics
Iron
Iron-Binding Proteins
Magnetic Resonance Spectroscopy
Microscopy, Fluorescence
Models, Molecular
Molecular Conformation
Molecular Dynamics Simulation
Point Mutation
Protein Denaturation
Protein Folding
Protein Structure, Tertiary
Recombinant Proteins
Solvents
Temperature
Time Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v7_n9_p_Roman
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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