DNA single strand breaks in peripheral blood lymphocytes induced by three nitroimidazole derivatives

Tinidazole (TNZ), ornidazole (ONZ) and metronidazole (MTZ) are antiparasitic drugs (nitroimidazole derivatives) that have proven to be effective against Trichomonas vaginalis, Entoamoeba histolytica, Giardia lamblia and Helicobacter pylori. The reduction of the nitro group and the generation of shor...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rodriguez Ferreiro, G., Cancino Badóas, L., Lopez-Nigro, M., Palermo, A., Mudry, M., González Elio, P., Carballo, M.A.
Formato:	JOUR
Materias:	Comet assay DNA damage Metronidazole Nitroimidazoles Ornidazole Tinidazole DNA metronidazole nitroimidazole derivative ornidazole reactive oxygen metabolite tinidazole aerobic metabolism antimicrobial activity article bacterial cell comet assay concentration response controlled study DNA strand breakage drug cytotoxicity human human cell lymphocyte mammal cell mutagenic activity priority journal Adult Antitrichomonal Agents Cells, Cultured Comet Assay DNA Damage DNA, Single-Stranded Dose-Response Relationship, Drug Humans Lymphocytes Male Giardia Giardia intestinalis Helicobacter Helicobacter pylori Mammalia Trichomonas vaginalis
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03784274_v132_n2_p109_RodriguezFerreiro
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

DNA single strand breaks in peripheral blood lymphocytes induced by three nitroimidazole derivatives
Publicado: (2002)

Cytogenetic evaluation of two nitroimidazole derivatives
por: López Nigro, M.M., et al.

Cytogenetic evaluation of two nitroimidazole derivatives
por: Palermo, Ana María, et al.
Publicado: (2003)

Analysis of apoptosis and DNA damage in bovine cumulus cells after exposure in vitro to different zinc concentrations
por: Anchordoquy, Juan Mateo, et al.
Publicado: (2011)

Nitroimidazole derivatives: Non-randomness sister chromatid exchanges in human peripheral blood lymphocytes
por: Carballo, M.A., et al.

Nitroimidazole derivatives: Non-randomness sister chromatid exchanges in human peripheral blood lymphocytes
por: Martinez Montaño, Romari Alejandra, et al.
Publicado: (2009)

Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes
por: Carballo, Marta A., et al.
Publicado: (2010)

Isolation of acetylated bile acids from the sponge Siphonochalina fortis and DNA damage evaluation by the comet assay
por: Cano, L.P.P., et al.

Isolation of acetylated bile acids from the sponge Siphonochalina fortis and DNA damage evaluation by the comet assay
Publicado: (2013)

Genotoxicity of the herbicide imazethapyr in mammalian cells by oxidative DNA damage evaluation using the Endo III and FPG alkaline comet assays
por: Soloneski, Sonia María Elsa, et al.
Publicado: (2017)

Genotoxicity of the herbicide formulation Roundup® (glyphosate) in broad-snouted caiman (Caiman latirostris) evidenced by the Comet assay and the Micronucleus test
por: Poletta, G.L., et al.

Genotoxicity of the herbicide formulation Roundup® (glyphosate) in broad-snouted caiman (Caiman latirostris) evidenced by the Comet assay and the Micronucleus test
por: Poletta, Gisela Laura, et al.
Publicado: (2009)

Evaluation of imazethapyr-induced DNA oxidative damage by alkaline Endo III- and Fpg-modified single-cell gel electrophoresis assay in Hypsiboas pulchellus tadpoles (Anura, Hylidae)
por: Pérez Iglesias, Juan Manuel, et al.
Publicado: (2017)

Biomarkers of genotoxicity and genomic instability in a non-human primate, Cebus libidinosus (Cebidae, Platyrrhini), exposed to nitroimidazole derivatives
por: Mudry, M.D., et al.

Development of glutaraldehyde cross-linked metronidazole loaded chitosan microcapsules: analysis of dissolution data using DD-Solver
por: Murtaza, Ghulam
Publicado: (2011)

Genotoxic effects of Roundup Full II® on lymphocytes of Chaetophractus villosus (Xenarthra, Mammalia): In vitro studies
por: Luaces, J.P., et al.

Biomarkers of genotoxicity and genomic instability in a non-human primate, Cebus libidinosus (Cebidae, Platyrrhini), exposed to nitroimidazole derivatives
por: Mudry, Marta Dolores, et al.
Publicado: (2011)

Genotoxic effects of Roundup Full II® on lymphocytes of Chaetophractus villosus (Xenarthra, Mammalia): In vitro studies
Publicado: (2017)

Use of short term genotoxicological tests to study cytotoxic, genotoxic and cell death mechanism of Metronidazole
por: López Nigro, M.M., et al.

Use of short term genotoxicological tests to study cytotoxic, genotoxic and cell death mechanism of Metronidazole
por: Mudry, Marta Dolores
Publicado: (2010)

Metronidazole induced DNA damage in somatic cells of Drosophila melanogaster
por: Palermo, A.M., et al.

Coelomocyte biomarkers in the earthworm Eisenia fetida exposed to 2,4,6-trinitrotoluene (TNT)
por: Fuchs, J., et al.

Coelomocyte biomarkers in the earthworm Eisenia fetida exposed to 2,4,6-trinitrotoluene (TNT)
Publicado: (2011)

Metronidazole induced DNA damage in somatic cells of Drosophila melanogaster
Publicado: (2013)

Toxicogenetic evaluation of metronidazole in the treatment of women infected with Trichomonas vaginalis
por: Carballo, M.A., et al.

Toxicogenetic evaluation of metronidazole in the treatment of women infected with Trichomonas vaginalis
por: Palermo, Ana María, et al.
Publicado: (2004)

Coupling between nucleotide excision repair and gene expression
por: Adrián E., C.B., et al.

Coupling between nucleotide excision repair and gene expression
Publicado: (2018)

Caiman latirostris (broad-snouted caiman) as a sentinel organism for genotoxic monitoring: Basal values determination of micronucleus and comet assay
por: Poletta, G.L., et al.

Relationship between genotoxic effects of breast cancer treatments and patient basal DNA integrity
por: Capitaine Funes, Juan, et al.
Publicado: (2017)

Caiman latirostris (broad-snouted caiman) as a sentinel organism for genotoxic monitoring: Basal values determination of micronucleus and comet assay
Publicado: (2008)

Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation
por: Lavaggi, M.L., et al.

Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection
por: Pregi, N., et al.

Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation
Publicado: (2010)

DNA repair kinetic of hydrogen peroxide and UVA/B induced lesions in peripheral blood leucocytes from xeroderma pigmentosum patients and healthy subjects
por: Prieto González, E.A., et al.

Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection
por: Pregi, Nicolás, et al.
Publicado: (2017)

High copper concentrations produce genotoxicity and cytotoxicity in bovine cumulus cells
por: Anchordoquy, Juan Mateo, et al.
Publicado: (2017)

DNA repair kinetic of hydrogen peroxide and UVA/B induced lesions in peripheral blood leucocytes from xeroderma pigmentosum patients and healthy subjects
Publicado: (2014)

Teratogenic Evaluation of Metronidazole and Ornidazole Using Drosophila melanogaster as an Experimental Model
por: Palermo, A.M., et al.

Teratogenic Evaluation of Metronidazole and Ornidazole Using Drosophila melanogaster as an Experimental Model
por: Palermo, Ana María, et al.
Publicado: (2004)