Pituitary tumors: Cell type-specific roles for BMP-4
BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it...
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todo:paper_03037207_v326_n1-2_p85_Labeur2023-10-03T15:19:52Z Pituitary tumors: Cell type-specific roles for BMP-4 Labeur, M. Páez-Pereda, M. Haedo, M. Arzt, E. Stalla, G.K. ACTH BMP-4 Pituitary tumors Prolactin Retinoic acid TGF-β bone morphogenetic protein 4 bromocriptine corticotropin cyclic AMP estradiol estrogen growth hormone releasing factor messenger RNA octreotide pasireotide prolactin recombinant follitropin Smad protein somatostatin derivative ACTH secreting cell article carcinogenesis cell proliferation cell type Cushing disease disease association drug mechanism drug potentiation genetic transcription gonadotropin secreting cell growth hormone secreting adenoma hormone release human hypophysis adenoma hypophysis tumor nonhuman priority journal prolactin secreting cell prolactinoma signal transduction Adrenocorticotropic Hormone Adult Animals Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins Humans Mice Pituitary ACTH Hypersecretion Pituitary Gland Pituitary Neoplasms Prolactin Prolactinoma Rats BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHβ subunit gene transcription in the murine gonadotroph cell line, LβT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid. © 2010 Elsevier Ireland Ltd. Fil:Labeur, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Páez-Pereda, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Haedo, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03037207_v326_n1-2_p85_Labeur |
| institution |
Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
ACTH BMP-4 Pituitary tumors Prolactin Retinoic acid TGF-β bone morphogenetic protein 4 bromocriptine corticotropin cyclic AMP estradiol estrogen growth hormone releasing factor messenger RNA octreotide pasireotide prolactin recombinant follitropin Smad protein somatostatin derivative ACTH secreting cell article carcinogenesis cell proliferation cell type Cushing disease disease association drug mechanism drug potentiation genetic transcription gonadotropin secreting cell growth hormone secreting adenoma hormone release human hypophysis adenoma hypophysis tumor nonhuman priority journal prolactin secreting cell prolactinoma signal transduction Adrenocorticotropic Hormone Adult Animals Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins Humans Mice Pituitary ACTH Hypersecretion Pituitary Gland Pituitary Neoplasms Prolactin Prolactinoma Rats |
| spellingShingle |
ACTH BMP-4 Pituitary tumors Prolactin Retinoic acid TGF-β bone morphogenetic protein 4 bromocriptine corticotropin cyclic AMP estradiol estrogen growth hormone releasing factor messenger RNA octreotide pasireotide prolactin recombinant follitropin Smad protein somatostatin derivative ACTH secreting cell article carcinogenesis cell proliferation cell type Cushing disease disease association drug mechanism drug potentiation genetic transcription gonadotropin secreting cell growth hormone secreting adenoma hormone release human hypophysis adenoma hypophysis tumor nonhuman priority journal prolactin secreting cell prolactinoma signal transduction Adrenocorticotropic Hormone Adult Animals Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins Humans Mice Pituitary ACTH Hypersecretion Pituitary Gland Pituitary Neoplasms Prolactin Prolactinoma Rats Labeur, M. Páez-Pereda, M. Haedo, M. Arzt, E. Stalla, G.K. Pituitary tumors: Cell type-specific roles for BMP-4 |
| topic_facet |
ACTH BMP-4 Pituitary tumors Prolactin Retinoic acid TGF-β bone morphogenetic protein 4 bromocriptine corticotropin cyclic AMP estradiol estrogen growth hormone releasing factor messenger RNA octreotide pasireotide prolactin recombinant follitropin Smad protein somatostatin derivative ACTH secreting cell article carcinogenesis cell proliferation cell type Cushing disease disease association drug mechanism drug potentiation genetic transcription gonadotropin secreting cell growth hormone secreting adenoma hormone release human hypophysis adenoma hypophysis tumor nonhuman priority journal prolactin secreting cell prolactinoma signal transduction Adrenocorticotropic Hormone Adult Animals Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins Humans Mice Pituitary ACTH Hypersecretion Pituitary Gland Pituitary Neoplasms Prolactin Prolactinoma Rats |
| description |
BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHβ subunit gene transcription in the murine gonadotroph cell line, LβT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid. © 2010 Elsevier Ireland Ltd. |
| format |
JOUR |
| author |
Labeur, M. Páez-Pereda, M. Haedo, M. Arzt, E. Stalla, G.K. |
| author_facet |
Labeur, M. Páez-Pereda, M. Haedo, M. Arzt, E. Stalla, G.K. |
| author_sort |
Labeur, M. |
| title |
Pituitary tumors: Cell type-specific roles for BMP-4 |
| title_short |
Pituitary tumors: Cell type-specific roles for BMP-4 |
| title_full |
Pituitary tumors: Cell type-specific roles for BMP-4 |
| title_fullStr |
Pituitary tumors: Cell type-specific roles for BMP-4 |
| title_full_unstemmed |
Pituitary tumors: Cell type-specific roles for BMP-4 |
| title_sort |
pituitary tumors: cell type-specific roles for bmp-4 |
| url |
http://hdl.handle.net/20.500.12110/paper_03037207_v326_n1-2_p85_Labeur |
| work_keys_str_mv |
AT labeurm pituitarytumorscelltypespecificrolesforbmp4 AT paezperedam pituitarytumorscelltypespecificrolesforbmp4 AT haedom pituitarytumorscelltypespecificrolesforbmp4 AT arzte pituitarytumorscelltypespecificrolesforbmp4 AT stallagk pituitarytumorscelltypespecificrolesforbmp4 |
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