human hypophysis tumor nonhuman priority journal Animals Humans Pituitary Neoplasms article hypophysis adenoma messenger RNA prolactinoma protein expression ACTH secreting cell Cell Line, Tumor Mice Transcription Factors carcinogenesis controlled study hormone release pasireotide prolactin protein function unclassified drug Adrenocorticotropic Hormone BMP-4 Bone Morphogenetic Protein 4 Cushing disease Cushing's disease Gene Expression Profiling Pituitary ACTH Hypersecretion