Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology

Cytokines of the IL-6 or gp130 family regulate many cellular responses and play regulatory roles in numerous tissues, and are placed as auto-paracrine regulators of pituitary function acting in normal and tumoral anterior pituitary cells. Especially, IL-6 has a regulatory role in the hormone secreti...

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Autores principales: Fuertes, M., Gerez, J., Haedo, M., Giacomini, D., Páez-Pereda, M., Labeur, M., Stalla, G.K., Arzt, E.
Formato: SER
Materias:
cytokine
glycoprotein gp 130
hypoxia inducible factor 1
I kappa B
interleukin 6
messenger RNA
angiogenesis
carcinogenesis
clone
cytology
gene overexpression
hormone release
human
hypophysis adenoma
hypophysis tumor
hypoxia
priority journal
protein function
review
Animals
Cytokine Receptor gp130
Gene Expression Profiling
Humans
Interleukin-6
Pituitary Neoplasms
Transcription Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03013073_v38_n_p1_Fuertes
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_03013073_v38_n_p1_Fuertes
record_format dspace
spelling todo:paper_03013073_v38_n_p1_Fuertes2023-10-03T15:18:19Z Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology Fuertes, M. Gerez, J. Haedo, M. Giacomini, D. Páez-Pereda, M. Labeur, M. Stalla, G.K. Arzt, E. cytokine glycoprotein gp 130 hypoxia inducible factor 1 I kappa B interleukin 6 messenger RNA angiogenesis carcinogenesis clone cytology gene overexpression hormone release human hypophysis adenoma hypophysis tumor hypoxia priority journal protein function review Animals Cytokine Receptor gp130 Gene Expression Profiling Humans Interleukin-6 Pituitary Neoplasms Transcription Factors Cytokines of the IL-6 or gp130 family regulate many cellular responses and play regulatory roles in numerous tissues, and are placed as auto-paracrine regulators of pituitary function acting in normal and tumoral anterior pituitary cells. Especially, IL-6 has a regulatory role in the hormone secretion and growth of the anterior pituitary and is involved in adenoma pathogenesis. Recently, IL-6 has been shown to mediate oncogene-induced senescence (OIS). IL-6 might participate in such a process in adenomas pituitary as well. From pituitary tumoral gp130 overexpressing cells, an unknown protein, RSUME, has been cloned. RSUME is induced by hypoxia in pituitary tumors and regulate pathways involved in angiogenic and tumorigenic processes (NF-κB/IκB and HIF-1α pathways). Thus, it could have an important role in the development of the pituitary tumors. Copyright © 2010 S. Karger AG, Basel. Fil:Gerez, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Haedo, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Giacomini, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Páez-Pereda, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Labeur, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. SER info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03013073_v38_n_p1_Fuertes
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic cytokine
glycoprotein gp 130
hypoxia inducible factor 1
I kappa B
interleukin 6
messenger RNA
angiogenesis
carcinogenesis
clone
cytology
gene overexpression
hormone release
human
hypophysis adenoma
hypophysis tumor
hypoxia
priority journal
protein function
review
Animals
Cytokine Receptor gp130
Gene Expression Profiling
Humans
Interleukin-6
Pituitary Neoplasms
Transcription Factors
spellingShingle cytokine
glycoprotein gp 130
hypoxia inducible factor 1
I kappa B
interleukin 6
messenger RNA
angiogenesis
carcinogenesis
clone
cytology
gene overexpression
hormone release
human
hypophysis adenoma
hypophysis tumor
hypoxia
priority journal
protein function
review
Animals
Cytokine Receptor gp130
Gene Expression Profiling
Humans
Interleukin-6
Pituitary Neoplasms
Transcription Factors
Fuertes, M.
Gerez, J.
Haedo, M.
Giacomini, D.
Páez-Pereda, M.
Labeur, M.
Stalla, G.K.
Arzt, E.
Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
topic_facet cytokine
glycoprotein gp 130
hypoxia inducible factor 1
I kappa B
interleukin 6
messenger RNA
angiogenesis
carcinogenesis
clone
cytology
gene overexpression
hormone release
human
hypophysis adenoma
hypophysis tumor
hypoxia
priority journal
protein function
review
Animals
Cytokine Receptor gp130
Gene Expression Profiling
Humans
Interleukin-6
Pituitary Neoplasms
Transcription Factors
description Cytokines of the IL-6 or gp130 family regulate many cellular responses and play regulatory roles in numerous tissues, and are placed as auto-paracrine regulators of pituitary function acting in normal and tumoral anterior pituitary cells. Especially, IL-6 has a regulatory role in the hormone secretion and growth of the anterior pituitary and is involved in adenoma pathogenesis. Recently, IL-6 has been shown to mediate oncogene-induced senescence (OIS). IL-6 might participate in such a process in adenomas pituitary as well. From pituitary tumoral gp130 overexpressing cells, an unknown protein, RSUME, has been cloned. RSUME is induced by hypoxia in pituitary tumors and regulate pathways involved in angiogenic and tumorigenic processes (NF-κB/IκB and HIF-1α pathways). Thus, it could have an important role in the development of the pituitary tumors. Copyright © 2010 S. Karger AG, Basel.
format SER
author Fuertes, M.
Gerez, J.
Haedo, M.
Giacomini, D.
Páez-Pereda, M.
Labeur, M.
Stalla, G.K.
Arzt, E.
author_facet Fuertes, M.
Gerez, J.
Haedo, M.
Giacomini, D.
Páez-Pereda, M.
Labeur, M.
Stalla, G.K.
Arzt, E.
author_sort Fuertes, M.
title Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
title_short Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
title_full Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
title_fullStr Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
title_full_unstemmed Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
title_sort cytokines and genes in pituitary tumorigenesis: rsume role in cell biology
url http://hdl.handle.net/20.500.12110/paper_03013073_v38_n_p1_Fuertes
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