An in vitro and in vivo evaluation of new potential trans-sialidase inhibitors of Trypanosoma cruzi predicted by a computational drug repositioning method

Chagas disease is one of the most important neglected parasitic diseases afflicting developed and undeveloped countries. There are currently limited options for inexpensive and secure pharmacological treatment. In this study, we employed a structure-based virtual screening protocol for 3180 FDA-appr...

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Detalles Bibliográficos
Autores principales: Lara-Ramirez, E.E., López-Cedillo, J.C., Nogueda-Torres, B., Kashif, M., Garcia-Perez, C., Bocanegra-Garcia, V., Agusti, R., Uhrig, M.L., Rivera, G.
Formato: JOUR
Materias:
Docking
Drug repositioning
FDA-drugs
Trans-sialidase
Trypanosoma cruzi
anabolic agent
antibiotic agent
antihistaminic agent
antihypertensive agent
azlocillin
cardiac glycoside
cefonicid
cefoperazone
cefsulodin
cromoglycate disodium
dicoumarol
doxazosin mesylate
flubendazole
ketanserin
raloxifene
salazosulfapyridine
sialidase inhibitor
telmisartan
terfenadine
troglitazone
ziprasidone
antiinflammatory agent
antiprotozoal agent
glycoprotein
sialidase
trans-sialidase
anion exchange chromatography
antihypertensive activity
antimicrobial activity
Article
chemical structure
controlled study
drug repositioning
drug screening
enzymatic assay
enzyme inhibition
enzyme mechanism
food and drug administration
in vitro study
in vivo study
nonhuman
sialylation
animal
antagonists and inhibitors
chemistry
drug effects
mouse
procedures
structure activity relation
Animals
Anti-Inflammatory Agents
Antiprotozoal Agents
Drug Repositioning
Glycoproteins
Mice
Neuraminidase
Structure-Activity Relationship
Sulfasalazine
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02235234_v132_n_p249_LaraRamirez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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