Disturbance of cellular iron uptake and utilisation by aluminium

Aluminium (Al) affects erythropoiesis but the real mechanism of action is still unknown. Transferrin receptors (TfR) in K562 cells are able to bind Tf, when carrying either iron (Fe) or Al, with similar affinity. Then, the aim of this work was to determine whether Al could interfere with the cellula...

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Detalles Bibliográficos
Autores principales: Pérez, G., Garbossa, G., Di Risio, C., Vittori, D., Nesse, A.
Formato: JOUR
Materias:
Aluminium toxicity
Haem synthesis
Haemoglobin synthesis
Iron metabolism
K562 cell line
aluminum
butyric acid
heme
hemin
iron 59
transferrin receptor
binding affinity
cell count
cell culture
cell differentiation
cell growth
cell level
cell metabolism
cell stimulation
cell strain
conference paper
controlled study
erythroid cell
erythropoiesis
heme synthesis
hemoglobin synthesis
human
human cell
iron transport
receptor binding
Aluminum
Apoproteins
Barbiturates
Biological Transport
Cell Differentiation
Heme
Hemin
Hemoglobins
Humans
Iron
K562 Cells
Leukemia, Erythroblastic, Acute
Radioisotopes
Transferrin
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01620134_v87_n1_p21_Perez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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