Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction

Two heparan sulphates, of different N- and O-sulphate content and iduronic/ glucuronic acid ratio (HS I and HS II), were submitted to partial periodate oxidation, borohydride reduction and subsequent O-sulphation. The sulphated derivatives showed increased anticoagulant activities by APTT assay and...

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Detalles Bibliográficos
Autores principales:	Kovensky, J., Fernández Cirelli, A.
Formato:	JOUR
Materias:	Assays Carboxylic acids Chemical modification Composition effects Degradation Derivatives Oxidation Reduction Borohydride reduction Glycosaminoglycans Heparan sulfates Heparinase Iduronic/glucoronic acid ratio Periodate oxidation Sulphation Polysaccharides
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01448617_v31_n4_p211_Kovensky
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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