Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction

Two heparan sulphates, of different N- and O-sulphate content and iduronic/ glucuronic acid ratio (HS I and HS II), were submitted to partial periodate oxidation, borohydride reduction and subsequent O-sulphation. The sulphated derivatives showed increased anticoagulant activities by APTT assay and...

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Autores principales: Kovensky, J., Fernández Cirelli, A.
Formato: JOUR
Materias:
Assays
Carboxylic acids
Chemical modification
Composition effects
Degradation
Derivatives
Oxidation
Reduction
Borohydride reduction
Glycosaminoglycans
Heparan sulfates
Heparinase
Iduronic/glucoronic acid ratio
Periodate oxidation
Sulphation
Polysaccharides
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01448617_v31_n4_p211_Kovensky
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_01448617_v31_n4_p211_Kovensky2023-10-03T14:59:42Z Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction Kovensky, J. Fernández Cirelli, A. Assays Carboxylic acids Chemical modification Composition effects Degradation Derivatives Oxidation Reduction Borohydride reduction Glycosaminoglycans Heparan sulfates Heparinase Iduronic/glucoronic acid ratio Periodate oxidation Sulphation Polysaccharides Two heparan sulphates, of different N- and O-sulphate content and iduronic/ glucuronic acid ratio (HS I and HS II), were submitted to partial periodate oxidation, borohydride reduction and subsequent O-sulphation. The sulphated derivatives showed increased anticoagulant activities by APTT assay and were significantly degraded by heparinase. © 1997 Published by Elsevier Science Ltd. All rights reserved. Fil:Kovensky, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Fernández Cirelli, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01448617_v31_n4_p211_Kovensky
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Assays
Carboxylic acids
Chemical modification
Composition effects
Degradation
Derivatives
Oxidation
Reduction
Borohydride reduction
Glycosaminoglycans
Heparan sulfates
Heparinase
Iduronic/glucoronic acid ratio
Periodate oxidation
Sulphation
Polysaccharides
spellingShingle Assays
Carboxylic acids
Chemical modification
Composition effects
Degradation
Derivatives
Oxidation
Reduction
Borohydride reduction
Glycosaminoglycans
Heparan sulfates
Heparinase
Iduronic/glucoronic acid ratio
Periodate oxidation
Sulphation
Polysaccharides
Kovensky, J.
Fernández Cirelli, A.
Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction
topic_facet Assays
Carboxylic acids
Chemical modification
Composition effects
Degradation
Derivatives
Oxidation
Reduction
Borohydride reduction
Glycosaminoglycans
Heparan sulfates
Heparinase
Iduronic/glucoronic acid ratio
Periodate oxidation
Sulphation
Polysaccharides
description Two heparan sulphates, of different N- and O-sulphate content and iduronic/ glucuronic acid ratio (HS I and HS II), were submitted to partial periodate oxidation, borohydride reduction and subsequent O-sulphation. The sulphated derivatives showed increased anticoagulant activities by APTT assay and were significantly degraded by heparinase. © 1997 Published by Elsevier Science Ltd. All rights reserved.
format JOUR
author Kovensky, J.
Fernández Cirelli, A.
author_facet Kovensky, J.
Fernández Cirelli, A.
author_sort Kovensky, J.
title Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction
title_short Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction
title_full Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction
title_fullStr Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction
title_full_unstemmed Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction
title_sort chemical modification of glycosaminoglycans. sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction
url http://hdl.handle.net/20.500.12110/paper_01448617_v31_n4_p211_Kovensky
work_keys_str_mv AT kovenskyj chemicalmodificationofglycosaminoglycanssulphationofheparansulphatederivativesobtainedbyperiodateoxidationborohydridereduction
AT fernandezcirellia chemicalmodificationofglycosaminoglycanssulphationofheparansulphatederivativesobtainedbyperiodateoxidationborohydridereduction
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