Induction of nitric oxide synthase and heme oxygenase activities by endotoxin in the rat adrenal cortex: Involvement of both signaling systems in the modulation of ACTH-dependent steroid production

The present study was designed to investigate the effect of lipopolysaccharide (LPS) on the expression levels and activities of the nitric oxide synthase (NOS) and heme oxygenase (HO) systems in the rat adrenal gland. Both enzymatic activities were significantly increased in this tissue after in viv...

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Detalles Bibliográficos
Autores principales: Grion, N., Repetto, E.M., Pomeraniec, Y., Martinez Calejman, C., Astort, F., Sanchez, R., Pignataro, O.P., Arias, P., Cymeryng, C.B.
Formato: JOUR
Materias:
bacterium lipopolysaccharide
corticotropin
endotoxin
heme oxygenase
inducible nitric oxide synthase
n(g) nitroarginine methyl ester
neuronal nitric oxide synthase
protoporphyrin tin
adrenal function
animal experiment
animal tissue
article
controlled study
enzyme activity
enzyme analysis
enzyme inhibition
genetic code
hormone action
hormone determination
immunomodulation
in vivo study
male
nonhuman
priority journal
protein expression
rat
signal transduction
steroidogenesis
Adrenal Cortex
Adrenocorticotropic Hormone
Animals
Corticosterone
Enzyme Activation
Enzyme Inhibitors
Gene Expression Regulation, Bacterial
Heme Oxygenase-1
Lipopolysaccharides
Male
Metalloporphyrins
NG-Nitroarginine Methyl Ester
Nitric Oxide Synthase
Nitric Oxide Synthase Type II
Protoporphyrins
Random Allocation
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger
Stimulation, Chemical
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00220795_v194_n1_p11_Grion
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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