The effect of griseofulvin on the heme pathway-II. An exhaustive analysis during short and long-term challenge

1. A clear biphasic response of the enzyme activities as a function of intoxication time due to the topical cutaneous griseofulvin treatment was observed. 2. The initial acute induction of ALA-S activity would be due to depletion of free heme in the regulatory pool caused by cytochrome P 450 destruc...

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Detalles Bibliográficos
Autores principales: Buzaleh, Ana María, Afonso, Susana Graciela, Vázquez, Elba Susana, Batlle, Alcira María del Carmen
Publicado: 1991
Materias:
5 aminolevulinate synthase
griseofulvin
porphobilinogen deaminase
porphobilinogen synthase
porphobilinogenase
porphyrin
unclassified drug
uroporphyrinogen iii synthase
animal experiment
animal tissue
article
enzyme activity
heme synthesis
liver
male
metabolism
mouse
nonhuman
oral drug administration
porphyria
priority journal
tissue culture
5-Aminolevulinate Synthetase
Ammonia-Lyases
Animal
Cell Nucleus
Cytochrome P-450 Enzyme System
Cytosol
Griseofulvin
Heme
In Vitro
Liver
Male
Mice
Mitochondria, Liver
Porphobilinogen Synthase
Porphyrins
Proteins
Support, Non-U.S. Gov't
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v22_n6_p1179_Navone
http://hdl.handle.net/20.500.12110/paper_03063623_v22_n6_p1179_Navone
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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