nonhuman Mice mouse animal experiment article controlled study male priority journal Liver enzyme activity animal tissue Male Animals 5 aminolevulinate synthase Heme heme isoflurane Animal Support, Non-U.S. Gov't enflurane animal model griseofulvin heme synthesis metabolism 5-Aminolevulinate Synthetase Enflurane Griseofulvin Isoflurane heme oxygenase intraperitoneal drug administration