Antimicrobial activity of Bothrops alternatus venom from the Northeast of Argentine

This study was undertaken to evaluate the antimicro- bial activity on Gram-negative and Gram-positive bacteria of the venom from Bothrops alternatus, specie responsible for most of snakebites in North-eastern Argentina. This activity was investigat- ed against Escherichia coli (ATCC 25922),...

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Autores principales: Bustillo, Soledad, Leiva, Laura Cristina, Merino, Luis Antonio, Acosta, Ofelia Cristina, Bal de Kier Joffé, Elisa Dora, Gorodner, Jorge Osvaldo
Formato: Artículo
Lenguaje:Inglés
Publicado: Asociación Latinoamericana de Microbiología. Asociación Mexicana de Microbiología 2026
Materias:
Antimicrobial
Bsnake venom
Bothrops alternatus
Antimicrobiana
Bactericida
Veneno de serpiente
Acceso en línea:http://repositorio.unne.edu.ar/handle/123456789/60035
Aporte de:
RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) de Universidad Nacional del Nordeste
id I48-R184-123456789-60035
record_format dspace
spelling I48-R184-123456789-600352026-02-12T12:53:37Z Antimicrobial activity of Bothrops alternatus venom from the Northeast of Argentine Bustillo, Soledad Leiva, Laura Cristina Merino, Luis Antonio Acosta, Ofelia Cristina Bal de Kier Joffé, Elisa Dora Gorodner, Jorge Osvaldo Antimicrobial Bsnake venom Bothrops alternatus Antimicrobiana Bactericida Veneno de serpiente This study was undertaken to evaluate the antimicro- bial activity on Gram-negative and Gram-positive bacteria of the venom from Bothrops alternatus, specie responsible for most of snakebites in North-eastern Argentina. This activity was investigat- ed against Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853), and En- terococcus faecalis (ATCC 29212). Inhibitory halos values and re- duction of colony-forming unites (CFU) by dilution plate technique were determined. The bactericidal activity was higher for E. coli and S. aureus, in comparison to that for P. aeruginosa. E. faecalis was the most resistant organism tested to the action of venom solu- tions. The demonstrated bactericidal property of B. alternatus ven- om highlight it as a promising candidate for further studies accord- ing to detect which component, or components, are responsible of this activity, in order to then investigate their potential use as anti- microbial agent. La actividad antimicrobiana del veneno Bothrops al- ternatus, especie responsable de la mayoría de los accidentes ofídi- cos en el Nordeste de Argentina, fue evaluada sobre bacterias Gram-negativas y Gram-positivas. Esta actividad fue ensayada so- bre Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853), y Ente- rococcus faecalis (ATCC 29212). Se determinaron los valores de halos de inhibición y la reducción de formación de unidades for- madoras de colonias (CFU) por el método de dilución en placa. La actividad bactericida fue mayor para E. coli y S. aureus; en compa- ración con P. aeruginosa, E. faecalis fue el microorganismo eva- luado más resistente a la acción de las soluciones de veneno. La propiedad bactericida demostrada del veneno de B. alternatus es importante para poder luego determinar cuál componente, o com- ponentes, son responsables de dicha actividad e investigar su poten- cial uso como agente antimicrobiano. 2026-02-12T12:00:03Z 2026-02-12T12:00:03Z 2008 Artículo Bustillo, Soledad, et al., 2008. Antimicrobial activity of Bothrops alternatus venom from the Northeast of Argentine. Revista Latinoamericana de Microbiología. Cuernavaca: Asociación Latinoamericana de Microbiología. Asociación Mexicana de Microbiología, vol. 50, no. 3-4, p. 79-82. E-ISSN 0187-4640. 0034-9771 http://repositorio.unne.edu.ar/handle/123456789/60035 eng https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=24270 openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ application/pdf p. 79-82 application/pdf Asociación Latinoamericana de Microbiología. Asociación Mexicana de Microbiología Revista Latinoamericana de Microbiología, 2008, vol. 50, no. 3-4, p. 79-82.
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-184
collection RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
language Inglés
topic Antimicrobial
Bsnake venom
Bothrops alternatus
Antimicrobiana
Bactericida
Veneno de serpiente
spellingShingle Antimicrobial
Bsnake venom
Bothrops alternatus
Antimicrobiana
Bactericida
Veneno de serpiente
Bustillo, Soledad
Leiva, Laura Cristina
Merino, Luis Antonio
Acosta, Ofelia Cristina
Bal de Kier Joffé, Elisa Dora
Gorodner, Jorge Osvaldo
Antimicrobial activity of Bothrops alternatus venom from the Northeast of Argentine
topic_facet Antimicrobial
Bsnake venom
Bothrops alternatus
Antimicrobiana
Bactericida
Veneno de serpiente
description This study was undertaken to evaluate the antimicro- bial activity on Gram-negative and Gram-positive bacteria of the venom from Bothrops alternatus, specie responsible for most of snakebites in North-eastern Argentina. This activity was investigat- ed against Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853), and En- terococcus faecalis (ATCC 29212). Inhibitory halos values and re- duction of colony-forming unites (CFU) by dilution plate technique were determined. The bactericidal activity was higher for E. coli and S. aureus, in comparison to that for P. aeruginosa. E. faecalis was the most resistant organism tested to the action of venom solu- tions. The demonstrated bactericidal property of B. alternatus ven- om highlight it as a promising candidate for further studies accord- ing to detect which component, or components, are responsible of this activity, in order to then investigate their potential use as anti- microbial agent.
format Artículo
author Bustillo, Soledad
Leiva, Laura Cristina
Merino, Luis Antonio
Acosta, Ofelia Cristina
Bal de Kier Joffé, Elisa Dora
Gorodner, Jorge Osvaldo
author_facet Bustillo, Soledad
Leiva, Laura Cristina
Merino, Luis Antonio
Acosta, Ofelia Cristina
Bal de Kier Joffé, Elisa Dora
Gorodner, Jorge Osvaldo
author_sort Bustillo, Soledad
title Antimicrobial activity of Bothrops alternatus venom from the Northeast of Argentine
title_short Antimicrobial activity of Bothrops alternatus venom from the Northeast of Argentine
title_full Antimicrobial activity of Bothrops alternatus venom from the Northeast of Argentine
title_fullStr Antimicrobial activity of Bothrops alternatus venom from the Northeast of Argentine
title_full_unstemmed Antimicrobial activity of Bothrops alternatus venom from the Northeast of Argentine
title_sort antimicrobial activity of bothrops alternatus venom from the northeast of argentine
publisher Asociación Latinoamericana de Microbiología. Asociación Mexicana de Microbiología
publishDate 2026
url http://repositorio.unne.edu.ar/handle/123456789/60035
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