Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms

Accidents involving snakes from Bothrops spp. and Crotalus spp. constitute the most important cause of envenomation in Brazil and Argentina. Musa spp. (banana) have been reported to be used in popular medicine against snakebite by the members of the Canudos Settlement, located in Goiás. In this way,...

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Autores principales: Matos da Silva, Márcia, Pereira Alexandre, Gerso, Magalhães, Marta Regina, Torres, Ana Maria, Kato, Lucilia, Costa da Silva, Victória, Teixeira de Saboia Morais, Simone Maria, Garcia Rodriguez, Armando, Pacheco Fill, Taícia, Pereira, Alana Kelyene, Roque, Jussara, Souza Simão, Jorge Luiz, Pasqualotto Severino, Vanessa Gisele
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2025
Materias:
Musa spp.
Banana
Sap
Antivenom
Bothrops
Crotalus
Acceso en línea:http://repositorio.unne.edu.ar/handle/123456789/59355
Aporte de:
RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) de Universidad Nacional del Nordeste
id I48-R184-123456789-59355
record_format dspace
spelling I48-R184-123456789-593552025-12-18T12:10:10Z Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms Matos da Silva, Márcia Pereira Alexandre, Gerso Magalhães, Marta Regina Torres, Ana Maria Kato, Lucilia Costa da Silva, Victória Teixeira de Saboia Morais, Simone Maria Garcia Rodriguez, Armando Pacheco Fill, Taícia Pereira, Alana Kelyene Roque, Jussara Souza Simão, Jorge Luiz Pasqualotto Severino, Vanessa Gisele Musa spp. Banana Sap Antivenom Bothrops Crotalus Accidents involving snakes from Bothrops spp. and Crotalus spp. constitute the most important cause of envenomation in Brazil and Argentina. Musa spp. (banana) have been reported to be used in popular medicine against snakebite by the members of the Canudos Settlement, located in Goiás. In this way, the aim of this work was to evaluate the antivenom effect of the Ouro (AA), Prata (AAB), Prata-anã (AAB) and Figo (ABB) cultivars against in vitro (phospholipase, coagulation and proteolytic) and in vivo (lethality and toxicity) activities caused by the venoms and toxicity (Artemia salina nauplii and Danio rerio embryos) of Musa spp. as well as the annotation of chemical compounds possibly related to these activities. From the in vitro antiophidic tests with the sap, we observed 100% inhibition of the phospholipase and coagulant activities with the cultivars Prata-anã and Figo against the venoms of B. alternatus and C. d. collineatus, B. diporus and B. pauloensis, respectively, and neutralisation of the lethality against the B. diporus venom. It was observed that the cultivars of Musa spp. did not show toxicity against Artemia salina nauplii and Danio rerio embryos. The sap analysis via HPLC-MS/MS allowed the annotation of the 13 compounds: abscisic acid, shikimic acid, citric acid, quinic acid, afzelechin, Glp-hexose, glucose, sucrose, isorhamnetin-3-O-galactoside-6-raminoside, kaempferol-3-glucoside-3-raminoside, myricetin-3-O-rutinoside, procyanidin B1 and rutin. Therefore, it can be seen that Musa spp. is a potential therapeutic agent that can act to neutralise the effects caused by snakebites. 2025-12-15T11:31:19Z 2025-12-15T11:31:19Z 2023-06 Artículo Matos da Silva, Márcia, et al., 2023. Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms. Toxicon. Oxford: Elsevier, vol. 228, p. 1-12. E-ISSN 1879-3150. 0041-0101 http://repositorio.unne.edu.ar/handle/123456789/59355 eng https://doi.org/10.1016/j.toxicon.2023.107106 openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ application/pdf p. 1-12 application/pdf Elsevier Toxicon, 2023, vol. 228, p. 1-12.
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-184
collection RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
language Inglés
topic Musa spp.
Banana
Sap
Antivenom
Bothrops
Crotalus
spellingShingle Musa spp.
Banana
Sap
Antivenom
Bothrops
Crotalus
Matos da Silva, Márcia
Pereira Alexandre, Gerso
Magalhães, Marta Regina
Torres, Ana Maria
Kato, Lucilia
Costa da Silva, Victória
Teixeira de Saboia Morais, Simone Maria
Garcia Rodriguez, Armando
Pacheco Fill, Taícia
Pereira, Alana Kelyene
Roque, Jussara
Souza Simão, Jorge Luiz
Pasqualotto Severino, Vanessa Gisele
Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms
topic_facet Musa spp.
Banana
Sap
Antivenom
Bothrops
Crotalus
description Accidents involving snakes from Bothrops spp. and Crotalus spp. constitute the most important cause of envenomation in Brazil and Argentina. Musa spp. (banana) have been reported to be used in popular medicine against snakebite by the members of the Canudos Settlement, located in Goiás. In this way, the aim of this work was to evaluate the antivenom effect of the Ouro (AA), Prata (AAB), Prata-anã (AAB) and Figo (ABB) cultivars against in vitro (phospholipase, coagulation and proteolytic) and in vivo (lethality and toxicity) activities caused by the venoms and toxicity (Artemia salina nauplii and Danio rerio embryos) of Musa spp. as well as the annotation of chemical compounds possibly related to these activities. From the in vitro antiophidic tests with the sap, we observed 100% inhibition of the phospholipase and coagulant activities with the cultivars Prata-anã and Figo against the venoms of B. alternatus and C. d. collineatus, B. diporus and B. pauloensis, respectively, and neutralisation of the lethality against the B. diporus venom. It was observed that the cultivars of Musa spp. did not show toxicity against Artemia salina nauplii and Danio rerio embryos. The sap analysis via HPLC-MS/MS allowed the annotation of the 13 compounds: abscisic acid, shikimic acid, citric acid, quinic acid, afzelechin, Glp-hexose, glucose, sucrose, isorhamnetin-3-O-galactoside-6-raminoside, kaempferol-3-glucoside-3-raminoside, myricetin-3-O-rutinoside, procyanidin B1 and rutin. Therefore, it can be seen that Musa spp. is a potential therapeutic agent that can act to neutralise the effects caused by snakebites.
format Artículo
author Matos da Silva, Márcia
Pereira Alexandre, Gerso
Magalhães, Marta Regina
Torres, Ana Maria
Kato, Lucilia
Costa da Silva, Victória
Teixeira de Saboia Morais, Simone Maria
Garcia Rodriguez, Armando
Pacheco Fill, Taícia
Pereira, Alana Kelyene
Roque, Jussara
Souza Simão, Jorge Luiz
Pasqualotto Severino, Vanessa Gisele
author_facet Matos da Silva, Márcia
Pereira Alexandre, Gerso
Magalhães, Marta Regina
Torres, Ana Maria
Kato, Lucilia
Costa da Silva, Victória
Teixeira de Saboia Morais, Simone Maria
Garcia Rodriguez, Armando
Pacheco Fill, Taícia
Pereira, Alana Kelyene
Roque, Jussara
Souza Simão, Jorge Luiz
Pasqualotto Severino, Vanessa Gisele
author_sort Matos da Silva, Márcia
title Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms
title_short Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms
title_full Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms
title_fullStr Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms
title_full_unstemmed Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms
title_sort musa spp. cultivars as a neutralising source against some toxic activities of bothrops and crotalus genus snake venoms
publisher Elsevier
publishDate 2025
url http://repositorio.unne.edu.ar/handle/123456789/59355
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