Emergence of acute/subacute infant-juvenile paracoccidioidomycosis in Northeast Argentina : effect of climatic and anthropogenic changes?
Argentina has two endemic areas of paracoccidioidomycosis (PCM). Bordering Paraguay and Brazil, Northeast Argentina (NEA) comprises the area with the highest incidence where the chronic adult clinical form has historically been reported. Juvenile form in chil- dren and adolescents is rare in th...
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Oxford University Press
2024
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| Acceso en línea: | http://repositorio.unne.edu.ar/handle/123456789/54712 |
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I48-R184-123456789-547122025-03-28T23:02:22Z Emergence of acute/subacute infant-juvenile paracoccidioidomycosis in Northeast Argentina : effect of climatic and anthropogenic changes? Giusiano, Gustavo Emilio Aguirre, Clarisa Vratnica, Claudia Rojas, Florencia Dinorah Corallo, Teresa Cattana, María Emilia Fernández, Mariana Soledad Mussin, Javier Esteban Sosa, María de los Ángeles Paracoccidioidomycosis Infant/juvenile Ecological influences Argentina Argentina has two endemic areas of paracoccidioidomycosis (PCM). Bordering Paraguay and Brazil, Northeast Argentina (NEA) comprises the area with the highest incidence where the chronic adult clinical form has historically been reported. Juvenile form in chil- dren and adolescents is rare in this area since only one case was reported in the last 10 years. Despite this, between 2010 and 2012, several cases of acute/subacute clinical forms in children aged 10 to 16 (median 12) were detected. In the last decade, the NEA region has been exposed to ecological variations as consequences of certain climatic and anthro- pogenic changes, including El Nino–Southern Oscillation phenomenon during 2009, and ̃ deforestation. The region has also suffered from the significant ecological effects of the construction of one of the biggest hydroelectric dams of South America. This study aims to describe clinical and epidemiological aspects of acute/subacute PCM cases detected in children from NEA and to discuss climatic and anthropogenic changes as possible con- tributing factors in the emergence of this disease in children. This acute/subacute PCM cluster was characterized by severe disseminated and aggressive presentations to local- ized form, with a high spectrum of clinical manifestations uncommonly observed. Due to the lack of experience in acute/subacute PCM in children in the studied area and the atypical clinical manifestations observed, the diagnosis was delayed. In order to avoid misdiagnosis, a higher level of suspicion is now required in NEA and countries bordering the southern part of the endemic area, which are affected by the changes discussed in this article. 2024-08-15T13:07:11Z 2024-08-15T13:07:11Z 2019-01 Artículo Giusiano, Gustavo Emilio, et al., 2019. Emergence of acute/subacute infant-juvenile paracoccidioidomycosis in Northeast Argentina : Effect of climatic and anthropogenic changes?. Medical Mycology. Oxford: Oxford University Press, vol. 57, no. 1, p. 30-37. E-ISSN 1460-2709. http://repositorio.unne.edu.ar/handle/123456789/54712 eng https://doi.org/10.1093/mmy/myx153 openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ application/pdf p. 30-37 application/pdf Oxford University Press Medical Mycology, 2019, vol. 57, no 1, p. 30-37. |
| institution |
Universidad Nacional del Nordeste |
| institution_str |
I-48 |
| repository_str |
R-184 |
| collection |
RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) |
| language |
Inglés |
| topic |
Paracoccidioidomycosis Infant/juvenile Ecological influences Argentina |
| spellingShingle |
Paracoccidioidomycosis Infant/juvenile Ecological influences Argentina Giusiano, Gustavo Emilio Aguirre, Clarisa Vratnica, Claudia Rojas, Florencia Dinorah Corallo, Teresa Cattana, María Emilia Fernández, Mariana Soledad Mussin, Javier Esteban Sosa, María de los Ángeles Emergence of acute/subacute infant-juvenile paracoccidioidomycosis in Northeast Argentina : effect of climatic and anthropogenic changes? |
| topic_facet |
Paracoccidioidomycosis Infant/juvenile Ecological influences Argentina |
| description |
Argentina has two endemic areas of paracoccidioidomycosis (PCM). Bordering Paraguay
and Brazil, Northeast Argentina (NEA) comprises the area with the highest incidence
where the chronic adult clinical form has historically been reported. Juvenile form in chil-
dren and adolescents is rare in this area since only one case was reported in the last 10
years. Despite this, between 2010 and 2012, several cases of acute/subacute clinical forms
in children aged 10 to 16 (median 12) were detected. In the last decade, the NEA region has
been exposed to ecological variations as consequences of certain climatic and anthro-
pogenic changes, including El Nino–Southern Oscillation phenomenon during 2009, and ̃
deforestation. The region has also suffered from the significant ecological effects of the
construction of one of the biggest hydroelectric dams of South America. This study aims
to describe clinical and epidemiological aspects of acute/subacute PCM cases detected in
children from NEA and to discuss climatic and anthropogenic changes as possible con-
tributing factors in the emergence of this disease in children. This acute/subacute PCM
cluster was characterized by severe disseminated and aggressive presentations to local-
ized form, with a high spectrum of clinical manifestations uncommonly observed. Due
to the lack of experience in acute/subacute PCM in children in the studied area and the
atypical clinical manifestations observed, the diagnosis was delayed. In order to avoid
misdiagnosis, a higher level of suspicion is now required in NEA and countries bordering
the southern part of the endemic area, which are affected by the changes discussed in
this article. |
| format |
Artículo |
| author |
Giusiano, Gustavo Emilio Aguirre, Clarisa Vratnica, Claudia Rojas, Florencia Dinorah Corallo, Teresa Cattana, María Emilia Fernández, Mariana Soledad Mussin, Javier Esteban Sosa, María de los Ángeles |
| author_facet |
Giusiano, Gustavo Emilio Aguirre, Clarisa Vratnica, Claudia Rojas, Florencia Dinorah Corallo, Teresa Cattana, María Emilia Fernández, Mariana Soledad Mussin, Javier Esteban Sosa, María de los Ángeles |
| author_sort |
Giusiano, Gustavo Emilio |
| title |
Emergence of acute/subacute infant-juvenile paracoccidioidomycosis in Northeast Argentina : effect of climatic and anthropogenic changes? |
| title_short |
Emergence of acute/subacute infant-juvenile paracoccidioidomycosis in Northeast Argentina : effect of climatic and anthropogenic changes? |
| title_full |
Emergence of acute/subacute infant-juvenile paracoccidioidomycosis in Northeast Argentina : effect of climatic and anthropogenic changes? |
| title_fullStr |
Emergence of acute/subacute infant-juvenile paracoccidioidomycosis in Northeast Argentina : effect of climatic and anthropogenic changes? |
| title_full_unstemmed |
Emergence of acute/subacute infant-juvenile paracoccidioidomycosis in Northeast Argentina : effect of climatic and anthropogenic changes? |
| title_sort |
emergence of acute/subacute infant-juvenile paracoccidioidomycosis in northeast argentina : effect of climatic and anthropogenic changes? |
| publisher |
Oxford University Press |
| publishDate |
2024 |
| url |
http://repositorio.unne.edu.ar/handle/123456789/54712 |
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