Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur

Malassezia furfur is lipophilic and lipid-dependent yeast, inhabitant of human skin microbiota associated with several dermal disorders. In recent years, along with the advances in nanotechnology and the incentive to find new antimicrobialdrugs, there has been a growing interest in the utilization o...

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Autores principales: Mussin, Javier Esteban, Roldán, María Virginia, Rojas, Florencia Dinorah, Sosa, María de los Ángeles, Pellegri, Nora Susana, Giusiano, Gustavo Emilio
Formato: Artículo
Lenguaje:en_US
Publicado: Springer 2024
Materias:
Malassezia
Nanoparticles
Antifungal activity
Synergy
Acceso en línea:http://repositorio.unne.edu.ar/handle/123456789/54153
Aporte de:
RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) de Universidad Nacional del Nordeste
id I48-R184-123456789-54153
record_format dspace
spelling I48-R184-123456789-541532024-06-04T19:25:37Z Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur Mussin, Javier Esteban Roldán, María Virginia Rojas, Florencia Dinorah Sosa, María de los Ángeles Pellegri, Nora Susana Giusiano, Gustavo Emilio Malassezia Nanoparticles Antifungal activity Synergy Malassezia furfur is lipophilic and lipid-dependent yeast, inhabitant of human skin microbiota associated with several dermal disorders. In recent years, along with the advances in nanotechnology and the incentive to find new antimicrobialdrugs, there has been a growing interest in the utilization of nanoparticles for the treatment of skin microbial infections. This work aimed to study the in vitro inhibitory activity of silver nanoparticles (AgNP) against 41 M. furfurclinical isolates, visualize the interaction between AgNP-Malassezia, evaluate the synergism with ketoconazole (KTZ) and to produce an antimicrobial gel of AgNP?KTZ. The synthesized AgNP were randomly distributed around the yeastsurface and showed a fungicidal action with low minimal inhibitory concentration values. AgNP showed no antagonistic effect with KTZ. The broad-spectrum antimicrobial property with fungicidal action of AgNP and its accumulationin affected areas with a sustained release profile, added to the great antifungal activity of KTZ against Malassezia infections and other superficial mycoses, allowed us to obtain a gel based on carbopol formulated with AgNP?KTZwith the potential to improve the topical therapy of superficial malasseziosis, reduce the number of applications and, also, prevent the recurrence. 2024-05-31T11:35:58Z 2024-05-31T11:35:58Z 2019 Artículo Mussin, Javier Esteban, et al., 2019. Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur. Applied Microbiology and Biotechnology. Berlín: Springer, vol.9, no. 131, p. 1-9. ISSN 0175-7598. 0175-7598 http://repositorio.unne.edu.ar/handle/123456789/54153 en_US openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ application/pdf p. 1-9 application/pdf Springer Applied Microbiology and Biotechnology, 2019, vol.9, no. 131, p. 1-9.
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-184
collection RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
language en_US
topic Malassezia
Nanoparticles
Antifungal activity
Synergy
spellingShingle Malassezia
Nanoparticles
Antifungal activity
Synergy
Mussin, Javier Esteban
Roldán, María Virginia
Rojas, Florencia Dinorah
Sosa, María de los Ángeles
Pellegri, Nora Susana
Giusiano, Gustavo Emilio
Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
topic_facet Malassezia
Nanoparticles
Antifungal activity
Synergy
description Malassezia furfur is lipophilic and lipid-dependent yeast, inhabitant of human skin microbiota associated with several dermal disorders. In recent years, along with the advances in nanotechnology and the incentive to find new antimicrobialdrugs, there has been a growing interest in the utilization of nanoparticles for the treatment of skin microbial infections. This work aimed to study the in vitro inhibitory activity of silver nanoparticles (AgNP) against 41 M. furfurclinical isolates, visualize the interaction between AgNP-Malassezia, evaluate the synergism with ketoconazole (KTZ) and to produce an antimicrobial gel of AgNP?KTZ. The synthesized AgNP were randomly distributed around the yeastsurface and showed a fungicidal action with low minimal inhibitory concentration values. AgNP showed no antagonistic effect with KTZ. The broad-spectrum antimicrobial property with fungicidal action of AgNP and its accumulationin affected areas with a sustained release profile, added to the great antifungal activity of KTZ against Malassezia infections and other superficial mycoses, allowed us to obtain a gel based on carbopol formulated with AgNP?KTZwith the potential to improve the topical therapy of superficial malasseziosis, reduce the number of applications and, also, prevent the recurrence.
format Artículo
author Mussin, Javier Esteban
Roldán, María Virginia
Rojas, Florencia Dinorah
Sosa, María de los Ángeles
Pellegri, Nora Susana
Giusiano, Gustavo Emilio
author_facet Mussin, Javier Esteban
Roldán, María Virginia
Rojas, Florencia Dinorah
Sosa, María de los Ángeles
Pellegri, Nora Susana
Giusiano, Gustavo Emilio
author_sort Mussin, Javier Esteban
title Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
title_short Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
title_full Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
title_fullStr Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
title_full_unstemmed Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
title_sort antifungal activity of silver nanoparticles in combination with ketoconazole against malassezia furfur
publisher Springer
publishDate 2024
url http://repositorio.unne.edu.ar/handle/123456789/54153
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