Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina : a clinic and pathological correlation with special consideration on the central nervous system

Ipomoea carnea subsp. _istulosa, aguapei or mandiyura, is responsible for lysosomal storage in goats. The shrub contains several alkaloids, mainly swansonine which inhibits lysosomal α-mannosidase and Golgi mannosidase II. Poisoning occurs by inhibition of these hydrolases. There is neuronal vacuol...

Descripción completa

Detalles Bibliográficos
Autores principales: Ríos, Elvio Eduardo, Cholich, Luciana Andrea, Gimeno, Eduardo Juan, Guidi, María Guadalupe, Acosta, Ofelia Cristina
Formato: Artículo
Lenguaje:Inglés
Publicado: Colégio Brasileiro de Patologia Animal 2024
Materias:
Poisonous plants
Ipomoea carnea
Plant poisoning
Goats
CNS lesions
Transmission electron microscopy
Plantas toxicas
Caprinos
Intoxicacao por planta
CNS lesoes
Microscopia eletronica de transmissao
Acceso en línea:http://repositorio.unne.edu.ar/handle/123456789/53209
Aporte de:
RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) de Universidad Nacional del Nordeste
id I48-R184-123456789-53209
record_format dspace
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-184
collection RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
language Inglés
topic Poisonous plants
Ipomoea carnea
Plant poisoning
Goats
CNS lesions
Transmission electron microscopy
Plantas toxicas
Caprinos
Intoxicacao por planta
CNS lesoes
Microscopia eletronica de transmissao
spellingShingle Poisonous plants
Ipomoea carnea
Plant poisoning
Goats
CNS lesions
Transmission electron microscopy
Plantas toxicas
Caprinos
Intoxicacao por planta
CNS lesoes
Microscopia eletronica de transmissao
Ríos, Elvio Eduardo
Cholich, Luciana Andrea
Gimeno, Eduardo Juan
Guidi, María Guadalupe
Acosta, Ofelia Cristina
Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina : a clinic and pathological correlation with special consideration on the central nervous system
topic_facet Poisonous plants
Ipomoea carnea
Plant poisoning
Goats
CNS lesions
Transmission electron microscopy
Plantas toxicas
Caprinos
Intoxicacao por planta
CNS lesoes
Microscopia eletronica de transmissao
description Ipomoea carnea subsp. _istulosa, aguapei or mandiyura, is responsible for lysosomal storage in goats. The shrub contains several alkaloids, mainly swansonine which inhibits lysosomal α-mannosidase and Golgi mannosidase II. Poisoning occurs by inhibition of these hydrolases. There is neuronal vacuolation, endocrine dysfunction, cardiovascular and gastrointestinal injury, and immune disorders. Clinical signs and pathology of the experimental poisoning of goatsby Ipomoea carnea in Argentina are here described. Five goats received fresh leaves and stems of Ipomoea. At the beginning, the goats did not consume the plant, but later, it was preferred over any other forage. High dose induced rapid intoxication, whereas with low doses, the course of the toxicosis was more protracted. The goats were euthanized when they were recumbent. Cerebrum, cerebellum, medulla oblongata, pons and colliculi, were routinely processed for histology. In nine days, the following clinical signs developed: abnormal fascies, dilated nostrils and abnormal postures of the head, cephalic tremors and nystagmus, dif_iculty in standing. Subsequently, the goats had a tendency to fall, always to the left, with spastic convulsions.There was lack in coordination of voluntary movements due to Purkinje and deep nuclei neurons damage. The cochlear re_lex originated hyperre_lexia, abnormal posture, head movements and tremors. The withdrawal re_lex produced _lexor muscles hypersensitivity at the four legs, later depression and stupor. Abnormal responses to sounds were related to collicular lesions. Thalamic damage altered the withdrawal re_lex, showing incomplete reaction. The observed cervical hair bristling was attributed to a thalamic regulated nociceptive response. Depression may be associated with agonists of lysergic acid contained in Ipomoea. These clinical signs were correlated with lesions in different parts of the CNS.
format Artículo
author Ríos, Elvio Eduardo
Cholich, Luciana Andrea
Gimeno, Eduardo Juan
Guidi, María Guadalupe
Acosta, Ofelia Cristina
author_facet Ríos, Elvio Eduardo
Cholich, Luciana Andrea
Gimeno, Eduardo Juan
Guidi, María Guadalupe
Acosta, Ofelia Cristina
author_sort Ríos, Elvio Eduardo
title Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina : a clinic and pathological correlation with special consideration on the central nervous system
title_short Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina : a clinic and pathological correlation with special consideration on the central nervous system
title_full Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina : a clinic and pathological correlation with special consideration on the central nervous system
title_fullStr Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina : a clinic and pathological correlation with special consideration on the central nervous system
title_full_unstemmed Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina : a clinic and pathological correlation with special consideration on the central nervous system
title_sort experimental poisoning of goats by ipomoea carnea subsp. fistulosa in argentina : a clinic and pathological correlation with special consideration on the central nervous system
publisher Colégio Brasileiro de Patologia Animal
publishDate 2024
url http://repositorio.unne.edu.ar/handle/123456789/53209
work_keys_str_mv AT rioselvioeduardo experimentalpoisoningofgoatsbyipomoeacarneasubspfistulosainargentinaaclinicandpathologicalcorrelationwithspecialconsiderationonthecentralnervoussystem
AT cholichlucianaandrea experimentalpoisoningofgoatsbyipomoeacarneasubspfistulosainargentinaaclinicandpathologicalcorrelationwithspecialconsiderationonthecentralnervoussystem
AT gimenoeduardojuan experimentalpoisoningofgoatsbyipomoeacarneasubspfistulosainargentinaaclinicandpathologicalcorrelationwithspecialconsiderationonthecentralnervoussystem
AT guidimariaguadalupe experimentalpoisoningofgoatsbyipomoeacarneasubspfistulosainargentinaaclinicandpathologicalcorrelationwithspecialconsiderationonthecentralnervoussystem
AT acostaofeliacristina experimentalpoisoningofgoatsbyipomoeacarneasubspfistulosainargentinaaclinicandpathologicalcorrelationwithspecialconsiderationonthecentralnervoussystem
_version_ 1832344087832821760
spelling I48-R184-123456789-532092024-10-23T10:49:02Z Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina : a clinic and pathological correlation with special consideration on the central nervous system Ríos, Elvio Eduardo Cholich, Luciana Andrea Gimeno, Eduardo Juan Guidi, María Guadalupe Acosta, Ofelia Cristina Poisonous plants Ipomoea carnea Plant poisoning Goats CNS lesions Transmission electron microscopy Plantas toxicas Caprinos Intoxicacao por planta CNS lesoes Microscopia eletronica de transmissao Ipomoea carnea subsp. _istulosa, aguapei or mandiyura, is responsible for lysosomal storage in goats. The shrub contains several alkaloids, mainly swansonine which inhibits lysosomal α-mannosidase and Golgi mannosidase II. Poisoning occurs by inhibition of these hydrolases. There is neuronal vacuolation, endocrine dysfunction, cardiovascular and gastrointestinal injury, and immune disorders. Clinical signs and pathology of the experimental poisoning of goatsby Ipomoea carnea in Argentina are here described. Five goats received fresh leaves and stems of Ipomoea. At the beginning, the goats did not consume the plant, but later, it was preferred over any other forage. High dose induced rapid intoxication, whereas with low doses, the course of the toxicosis was more protracted. The goats were euthanized when they were recumbent. Cerebrum, cerebellum, medulla oblongata, pons and colliculi, were routinely processed for histology. In nine days, the following clinical signs developed: abnormal fascies, dilated nostrils and abnormal postures of the head, cephalic tremors and nystagmus, dif_iculty in standing. Subsequently, the goats had a tendency to fall, always to the left, with spastic convulsions.There was lack in coordination of voluntary movements due to Purkinje and deep nuclei neurons damage. The cochlear re_lex originated hyperre_lexia, abnormal posture, head movements and tremors. The withdrawal re_lex produced _lexor muscles hypersensitivity at the four legs, later depression and stupor. Abnormal responses to sounds were related to collicular lesions. Thalamic damage altered the withdrawal re_lex, showing incomplete reaction. The observed cervical hair bristling was attributed to a thalamic regulated nociceptive response. Depression may be associated with agonists of lysergic acid contained in Ipomoea. These clinical signs were correlated with lesions in different parts of the CNS. Ipomoea carnea subsp. fistulosa, aguapeí ou mandiyura, causa uma doenca de depósito lisossomal em caprinos. A planta contém vários alcalóides, principalmente swansonine, que inibe uma α-mannosidase lisossomal e uma mannosidase II do Golgi. A intoxicacao ocorre pela inibicao dessas hidrolases. Há vacuolizacao neuronal, disfuncao endocrina, lesoes cardiovasculares e gastrointestinais e disturbios imunologicos. No presente trabalho é descrita a intoxicacao experimental por Ipomoea carnea subsp. fistulosa em caprinos da Argentina. Cinco cabras receberam folhas frescas e ramos de Ipomoea. No comeco eles nao consumiram a planta, mas depois ela foi preferida a qualquer outras forrageiras. Altas doses induziram uma intoxicacao rápida, enquanto que com doses baixas demora mais tempo. As cabras foram sacri_icadas quando _icavam em decubito. Cérebro, cerebelo, medula oblonga, ponte e coliculos foram procesados rotineiramente para histologia. Aos nove dias, encontramos: fascie anormal, narinas dilatadas, posturas anormais da cabeca, tremores cefálicos e nistagmo, dificuldade para permanecer na estacao. Posteriormente, presentearam a tendencia de queda, sempre a esquerda, com convulsoes espasticas. Os neuronios de Purkinje e os os núcleos profundos foram dani_icados. Como consequencia, emergiu a falta de coordenacao de movimentos voluntarios. A hiper-reflexo coclear originou postura anormal, movimentos de cabeca e tremores. A retirada produz reflexos hipersensibilidade nos flexores dos quatro membros, depois depressao e letargia. As respostas anormais estao ligadas a lesoes do coliculo. Injurias no tálamo alteram o re_lexo de retirada, mostrando uma reacao incompleta. Os pelos ericados da regiao cervical podem representar uma resposta nociceptiva também regulada pelo talamo. A depressao pode estar associada com agonistas do ácido lisérgico presentes na Ipomoea. Esses sintomas estao relacionados com lesoes em diferentes partes do SNC. 2024-04-09T14:11:37Z 2024-04-09T14:11:37Z 2012 Artículo Ríos, Elvio Eduardo, et al., 2012. Experimental poisoning of goats by Ipomoea carnea subsp.fistulosa in Argentina : a clinic and pathological correlation with special consideration on the central nervous system. Pesquisa Veterinária Brasileira. Rio de Janeiro: Colégio Brasileiro de Patologia Animal, vol. 32, no. 1, p. 37-42. E-ISSN 1678-5150. 0100-736X http://repositorio.unne.edu.ar/handle/123456789/53209 eng openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ application/pdf p. 37-42 application/pdf Colégio Brasileiro de Patologia Animal Pesquisa Veterinária Brasileira, 2012, vol. 32, no. 1, p. 37-42.

Ejemplares similares