Efficacy of Argentine propolis formulation for topical treatment of canine otitis externa

The therapeutic effects of Argentine propolis ear drop formulation on canine otitis externa were evaluated. Forty-eight dogs with symptoms of otitis externa were randomly assigned to double–blinded, controlled clinical trial to evaluate the efficacy of topical formulation with propolis versus a to...

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Autores principales: Lozina, Laura Analía, Peichoto, María Elisa, Boehringer, Silvia Irene, Koscinczuk, Patricia, Granero, Gladys Ester, Acosta, Ofelia Cristina
Formato: Artículo
Lenguaje:Inglés
Publicado: Universidade Federal de Minas Gerais. Escola de Veterinária 2022
Materias:
Dog
Propolis
Glicerin-propylenglycol
Otitis externa
Cão
Própolis
Glicerina-propilenoglicol
Otite externa
Acceso en línea:http://repositorio.unne.edu.ar/handle/123456789/48889
Aporte de:
RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) de Universidad Nacional del Nordeste
id I48-R184-123456789-48889
record_format dspace
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-184
collection RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
language Inglés
topic Dog
Propolis
Glicerin-propylenglycol
Otitis externa
Cão
Própolis
Glicerina-propilenoglicol
Otite externa
spellingShingle Dog
Propolis
Glicerin-propylenglycol
Otitis externa
Cão
Própolis
Glicerina-propilenoglicol
Otite externa
Lozina, Laura Analía
Peichoto, María Elisa
Boehringer, Silvia Irene
Koscinczuk, Patricia
Granero, Gladys Ester
Acosta, Ofelia Cristina
Efficacy of Argentine propolis formulation for topical treatment of canine otitis externa
topic_facet Dog
Propolis
Glicerin-propylenglycol
Otitis externa
Cão
Própolis
Glicerina-propilenoglicol
Otite externa
description The therapeutic effects of Argentine propolis ear drop formulation on canine otitis externa were evaluated. Forty-eight dogs with symptoms of otitis externa were randomly assigned to double–blinded, controlled clinical trial to evaluate the efficacy of topical formulation with propolis versus a topical placebo in the treatment of otitis externa. The propolis preparation and placebo were administrated into both external ear canals, twice daily for 14 days. Throughout the study, clinical examination and microbiological analysis of dogs ear exudates were made. The most frequent microorganisms isolated in culture media were: Malassezia pachydermatis (54.2%), Staphylococcus aureus (43.8%), coagulase- negative Staphylococcus (25.0%), Pseudomonas aeruginosa (20.8%), Candida albicans (18.8%), Proteus mirabilis (16.7%), Streptococcus spp. (16.7%), Enteroccocus faecalis (12.5%), Escherichia coli (12.5%), Staphylococcus intermedius (6.3%), Klebsiella spp. (4.2%), and Candida glabrata (2.1%). Whereas the control group did not recover from the infectious ear disease, the propolis preparation exhibited antimicrobial activity against most of the microorganisms isolated from samples of the treated group. In addition, no propolis-adverse effects were observed. This allowed propolis-treated patients to show a significant improvement of the clinical parameters. Thus, this new Argentine propolis ear drop formulation may be used for topical treatment of otitis externa in dogs.
format Artículo
author Lozina, Laura Analía
Peichoto, María Elisa
Boehringer, Silvia Irene
Koscinczuk, Patricia
Granero, Gladys Ester
Acosta, Ofelia Cristina
author_facet Lozina, Laura Analía
Peichoto, María Elisa
Boehringer, Silvia Irene
Koscinczuk, Patricia
Granero, Gladys Ester
Acosta, Ofelia Cristina
author_sort Lozina, Laura Analía
title Efficacy of Argentine propolis formulation for topical treatment of canine otitis externa
title_short Efficacy of Argentine propolis formulation for topical treatment of canine otitis externa
title_full Efficacy of Argentine propolis formulation for topical treatment of canine otitis externa
title_fullStr Efficacy of Argentine propolis formulation for topical treatment of canine otitis externa
title_full_unstemmed Efficacy of Argentine propolis formulation for topical treatment of canine otitis externa
title_sort efficacy of argentine propolis formulation for topical treatment of canine otitis externa
publisher Universidade Federal de Minas Gerais. Escola de Veterinária
publishDate 2022
url http://repositorio.unne.edu.ar/handle/123456789/48889
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spelling I48-R184-123456789-488892024-10-23T10:49:29Z Efficacy of Argentine propolis formulation for topical treatment of canine otitis externa Eficácia da formulação da propólis Argentina para o tratamento tópico de otite externa canina Lozina, Laura Analía Peichoto, María Elisa Boehringer, Silvia Irene Koscinczuk, Patricia Granero, Gladys Ester Acosta, Ofelia Cristina Dog Propolis Glicerin-propylenglycol Otitis externa Cão Própolis Glicerina-propilenoglicol Otite externa The therapeutic effects of Argentine propolis ear drop formulation on canine otitis externa were evaluated. Forty-eight dogs with symptoms of otitis externa were randomly assigned to double–blinded, controlled clinical trial to evaluate the efficacy of topical formulation with propolis versus a topical placebo in the treatment of otitis externa. The propolis preparation and placebo were administrated into both external ear canals, twice daily for 14 days. Throughout the study, clinical examination and microbiological analysis of dogs ear exudates were made. The most frequent microorganisms isolated in culture media were: Malassezia pachydermatis (54.2%), Staphylococcus aureus (43.8%), coagulase- negative Staphylococcus (25.0%), Pseudomonas aeruginosa (20.8%), Candida albicans (18.8%), Proteus mirabilis (16.7%), Streptococcus spp. (16.7%), Enteroccocus faecalis (12.5%), Escherichia coli (12.5%), Staphylococcus intermedius (6.3%), Klebsiella spp. (4.2%), and Candida glabrata (2.1%). Whereas the control group did not recover from the infectious ear disease, the propolis preparation exhibited antimicrobial activity against most of the microorganisms isolated from samples of the treated group. In addition, no propolis-adverse effects were observed. This allowed propolis-treated patients to show a significant improvement of the clinical parameters. Thus, this new Argentine propolis ear drop formulation may be used for topical treatment of otitis externa in dogs. Os efeitos terapêuticos da formulação em gotas óticas de própolis procedentes da Argentina foram avaliados no tratamento da otite externa canina. Quarenta e oito cães com sintomas de otite externa foram distribuídos aleatoriamente em ensaio clínico duplo-cego controlado para avaliar a eficácia da formulação tópica com a própolis contra um placebo tópico no tratamento da otite externa. A preparação de própolis e placebo foi administrada em ambos os canais da orelha externa, duas vezes por dia, durante 14 dias. Ao longo do estudo, os cães foram submetidos a exame físico e à análise microbiológica de exsudatos auriculares. Os mais frequentes microrganismos isolados em meios de cultura foram: Malassezia pachydermatis (54,2%), Staphylococcus aureus (43,8%), Staphylococcus coagulase-negativo (25,0%), Pseudomonas aeruginosa (20,8%), Candida albicans (18,8%), Proteus mirabilis (16,7%), Streptococcus spp. (16,7%), Enterococcus faecalis (12,5%), Escherichia coli (12,5%), Staphylococcus intermedius (6,3%), Klebsiella spp. (4,2%) e Candida glabrata (2,1%). A preparação de própolis apresentou atividade antimicrobiana contra a maioria dos microrganismos isolados de amostras do grupo de tratamento, sendo que os do grupo-controle não se recuperaram da doença infecciosa auricular, e não foram observados efeitos adversos à própolis. Isso permitiu aos pacientes tratados com própolis melhora significativa dos parâmetros clínicos. Essa nova formulação da própolis argentina para o ouvido apresenta potencial utilidade no tratamento tópico da otite externa em cães. 2022-07-11T15:07:22Z 2022-07-11T15:07:22Z 2010 Artículo Lozina, Laura Analía, et al., 2010. Efficacy of Argentine propolis formulation for topical treatment of canine otitis externa. Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Belo Horizonte: Universidade Federal de Minas Gerais. Escola de Veterinária, vol. 62, no. 6, p. 1360-1366. e-ISSN 1678-4162. 0102-0935 http://repositorio.unne.edu.ar/handle/123456789/48889 eng openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ application/pdf application/pdf Universidade Federal de Minas Gerais. Escola de Veterinária Arquivo Brasileiro de Medicina Veterinária e Zootecnia, vol. 62, no. 6, p. 1360-1366.

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