Jatropha cake (jatropha curcas) : hepatotoxic implications
Jatropha has been highlighted as an oleaginous potential for the production of biofuel. The cake, produced by oil extraction, could be used in animal feed. However, some varieties of jatropha are toxic by limiting their incorporation into animal diets. The objective of this study was to evaluate t...
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| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
University of São Paulo. School of Veterinary Medicine and Animal Science
2022
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| Materias: | |
| Acceso en línea: | http://repositorio.unne.edu.ar/handle/123456789/48648 |
| Aporte de: |
| Sumario: | Jatropha has been highlighted as an oleaginous potential for the production of biofuel. The cake, produced by oil
extraction, could be used in animal feed. However, some varieties of jatropha are toxic by limiting their incorporation
into animal diets. The objective of this study was to evaluate the hepatotoxicity of diets added with jatropha cake –
JC (Jatropha curcas) in rats. Thirty-five (35) male Wistar adults rats (Rattus norvegicus) with initial weight of 352.1
± 26.8 g were used. The animals were fed for 21 days with the diets: control, 10, 25, 40 and 50% JC. In the feeding
with 50% JC the animals presented themselves prostrate and with piloerection. Development and survival decreased,
since the inclusion of JC in diets increased. In rats submitted to 10 and 25% JC there was an increase of 17.52% in the
hepatosomatic index in relation to the control group. Increase of JC in the rat diet promoted an increase in the activity
of ALT and AST enzymes. Anatomic-histopathological evaluation demonstrated that, regardless of the levels tested,
JC in rat diet causes hypertrophy of the hepatocytes, with a reduction in energy reserves. This study demonstrated
that the use of JC resulted in decreased food intake, associated with weight loss due to the clinical pattern of toxicity,
demonstrated by biochemical and histopathological changes in the liver. It was concluded that the inclusion of jatropha
cake in rat feeding presents high hepatotoxic potential leading to lesions in the liver parenchyma. |
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