Jatropha cake (jatropha curcas) : hepatotoxic implications
Jatropha has been highlighted as an oleaginous potential for the production of biofuel. The cake, produced by oil extraction, could be used in animal feed. However, some varieties of jatropha are toxic by limiting their incorporation into animal diets. The objective of this study was to evaluate t...
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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University of São Paulo. School of Veterinary Medicine and Animal Science
2022
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| Acceso en línea: | http://repositorio.unne.edu.ar/handle/123456789/48648 |
| Aporte de: |
| id |
I48-R184-123456789-48648 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional del Nordeste |
| institution_str |
I-48 |
| repository_str |
R-184 |
| collection |
RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) |
| language |
Inglés |
| topic |
Toxic The hepatotoxicity Animal feed Tóxico À hepatotoxicidade Alimentação animal |
| spellingShingle |
Toxic The hepatotoxicity Animal feed Tóxico À hepatotoxicidade Alimentação animal Honorato da Silva, Claucia Aparecida Da Silva, César José Flores Quintana, Carolina Isabel Mendonça, Simone Nascimento, Camila Aparecida Marcondes, Vanessa Menegatti Parente, Bruna Oliveira Machado de Araújo, Miguel Augusto Jatropha cake (jatropha curcas) : hepatotoxic implications |
| topic_facet |
Toxic The hepatotoxicity Animal feed Tóxico À hepatotoxicidade Alimentação animal |
| description |
Jatropha has been highlighted as an oleaginous potential for the production of biofuel. The cake, produced by oil
extraction, could be used in animal feed. However, some varieties of jatropha are toxic by limiting their incorporation
into animal diets. The objective of this study was to evaluate the hepatotoxicity of diets added with jatropha cake –
JC (Jatropha curcas) in rats. Thirty-five (35) male Wistar adults rats (Rattus norvegicus) with initial weight of 352.1
± 26.8 g were used. The animals were fed for 21 days with the diets: control, 10, 25, 40 and 50% JC. In the feeding
with 50% JC the animals presented themselves prostrate and with piloerection. Development and survival decreased,
since the inclusion of JC in diets increased. In rats submitted to 10 and 25% JC there was an increase of 17.52% in the
hepatosomatic index in relation to the control group. Increase of JC in the rat diet promoted an increase in the activity
of ALT and AST enzymes. Anatomic-histopathological evaluation demonstrated that, regardless of the levels tested,
JC in rat diet causes hypertrophy of the hepatocytes, with a reduction in energy reserves. This study demonstrated
that the use of JC resulted in decreased food intake, associated with weight loss due to the clinical pattern of toxicity,
demonstrated by biochemical and histopathological changes in the liver. It was concluded that the inclusion of jatropha
cake in rat feeding presents high hepatotoxic potential leading to lesions in the liver parenchyma. |
| format |
Artículo |
| author |
Honorato da Silva, Claucia Aparecida Da Silva, César José Flores Quintana, Carolina Isabel Mendonça, Simone Nascimento, Camila Aparecida Marcondes, Vanessa Menegatti Parente, Bruna Oliveira Machado de Araújo, Miguel Augusto |
| author_facet |
Honorato da Silva, Claucia Aparecida Da Silva, César José Flores Quintana, Carolina Isabel Mendonça, Simone Nascimento, Camila Aparecida Marcondes, Vanessa Menegatti Parente, Bruna Oliveira Machado de Araújo, Miguel Augusto |
| author_sort |
Honorato da Silva, Claucia Aparecida |
| title |
Jatropha cake (jatropha curcas) : hepatotoxic implications |
| title_short |
Jatropha cake (jatropha curcas) : hepatotoxic implications |
| title_full |
Jatropha cake (jatropha curcas) : hepatotoxic implications |
| title_fullStr |
Jatropha cake (jatropha curcas) : hepatotoxic implications |
| title_full_unstemmed |
Jatropha cake (jatropha curcas) : hepatotoxic implications |
| title_sort |
jatropha cake (jatropha curcas) : hepatotoxic implications |
| publisher |
University of São Paulo. School of Veterinary Medicine and Animal Science |
| publishDate |
2022 |
| url |
http://repositorio.unne.edu.ar/handle/123456789/48648 |
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I48-R184-123456789-486482024-10-23T10:48:54Z Jatropha cake (jatropha curcas) : hepatotoxic implications Torta de pinhão-manso (jatropha curcas) : implicações hepatotóxicas Honorato da Silva, Claucia Aparecida Da Silva, César José Flores Quintana, Carolina Isabel Mendonça, Simone Nascimento, Camila Aparecida Marcondes, Vanessa Menegatti Parente, Bruna Oliveira Machado de Araújo, Miguel Augusto Toxic The hepatotoxicity Animal feed Tóxico À hepatotoxicidade Alimentação animal Jatropha has been highlighted as an oleaginous potential for the production of biofuel. The cake, produced by oil extraction, could be used in animal feed. However, some varieties of jatropha are toxic by limiting their incorporation into animal diets. The objective of this study was to evaluate the hepatotoxicity of diets added with jatropha cake – JC (Jatropha curcas) in rats. Thirty-five (35) male Wistar adults rats (Rattus norvegicus) with initial weight of 352.1 ± 26.8 g were used. The animals were fed for 21 days with the diets: control, 10, 25, 40 and 50% JC. In the feeding with 50% JC the animals presented themselves prostrate and with piloerection. Development and survival decreased, since the inclusion of JC in diets increased. In rats submitted to 10 and 25% JC there was an increase of 17.52% in the hepatosomatic index in relation to the control group. Increase of JC in the rat diet promoted an increase in the activity of ALT and AST enzymes. Anatomic-histopathological evaluation demonstrated that, regardless of the levels tested, JC in rat diet causes hypertrophy of the hepatocytes, with a reduction in energy reserves. This study demonstrated that the use of JC resulted in decreased food intake, associated with weight loss due to the clinical pattern of toxicity, demonstrated by biochemical and histopathological changes in the liver. It was concluded that the inclusion of jatropha cake in rat feeding presents high hepatotoxic potential leading to lesions in the liver parenchyma. O pinhão-manso tem se destacado como oleaginosa potencial para a produção de biocombustível. A torta, coproduto da extração do óleo, poderia ser utilizada na alimentação animal. No entanto, algumas variedades de pinhão-manso são tóxicas, limitando sua incorporação em dietas animais. Objetivou-se neste estudo avaliar a hepatotoxicidade de dietas acrescidas de torta de pinhão-manso (Jatropha curcas) em ratos. Foram utilizados trinta e cinco (35) ratos Wistar (Rattus norvergicus) machos adultos com peso inicial de 352,1 ± 26,8 g. Os animais foram alimentados por 21 dias com as dietas: controle, 10, 25, 40 e 50% TPM. Na alimentação com 50% TPM os animais apresentaram-se prostrados e com piloereção. O desenvolvimento e a sobrevivência apresentaram diminuição conforme o aumento da inclusão de TPM nas dietas. Em ratos submetidos a 10 e 25% TPM houve aumento de 17,52% no índice hepatossomático em relação ao grupo controle. O aumento de TPM na dieta de ratos promoveu aumento da atividade das enzimas ALT e AST. A avaliação anatomo-histopatológica revelou que, independentemente dos níveis testados, a TPM na alimentação de ratos provoca hipertrofia dos hepatócitos, com redução das reservas energéticas. Este estudo demonstrou que a utilização de TPM resultou em diminuição do consumo de alimento associado à perda de peso devido ao quadro clínico de toxicidade demonstrado pelas alterações bioquímica e histopatológica no fígado. Conclui-se que a inclusão de torta de pinhão-manso na alimentação de ratos apresenta alto potencial hepatotóxico levando a lesões no parênquima hepático. 2022-07-04T13:35:19Z 2022-07-04T13:35:19Z 2017 Artículo Honorato da Silva, Claucia Aparecida, et al., 2017. Jatropha cake (jatropha curcas) : hepatotoxic implications. Brazilian Journal of Veterinary Research and Animal Science. São Paulo: University of São Paulo. School of Veterinary Medicine and Animal Science, vol. 54, no. 2, p. 101-108. ISSN-e 1678-4456. 1413-9596 http://repositorio.unne.edu.ar/handle/123456789/48648 eng openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ application/pdf application/pdf University of São Paulo. School of Veterinary Medicine and Animal Science Brazilian Journal of Veterinary Research and Animal Science, 2017, vol. 54, no. 2, p. 101-108. |