Longitudinal development of the spine and spinal cord in human fetuses

Objective: The spinal cord extends from the foramen magnum to the sacrum in the human fetus at the beginning of the 2nd quarter. However, the medullary cone is located at or above the level of the second lumbar vertebra at birth. The objective is to determine the difference between the rates of...

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Autores principales: Manzone, Patricio, Guidobono, Juan Armando, Forlino, Daniel
Formato: Artículo
Lenguaje:Inglés
Publicado: Sociedad Brasileira de Columna 2022
Materias:
Fetal development
Spine
Spinal cord
Desenvolvimento fetal
Coluna vertebral
Medula espinal
Desarrollo fetal
Columna vertebral
Médula espinal
Acceso en línea:http://repositorio.unne.edu.ar/handle/123456789/48475
Aporte de:
RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) de Universidad Nacional del Nordeste
id I48-R184-123456789-48475
record_format dspace
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-184
collection RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
language Inglés
topic Fetal development
Spine
Spinal cord
Desenvolvimento fetal
Coluna vertebral
Medula espinal
Desarrollo fetal
Columna vertebral
Médula espinal
spellingShingle Fetal development
Spine
Spinal cord
Desenvolvimento fetal
Coluna vertebral
Medula espinal
Desarrollo fetal
Columna vertebral
Médula espinal
Manzone, Patricio
Guidobono, Juan Armando
Forlino, Daniel
Longitudinal development of the spine and spinal cord in human fetuses
topic_facet Fetal development
Spine
Spinal cord
Desenvolvimento fetal
Coluna vertebral
Medula espinal
Desarrollo fetal
Columna vertebral
Médula espinal
description Objective: The spinal cord extends from the foramen magnum to the sacrum in the human fetus at the beginning of the 2nd quarter. However, the medullary cone is located at or above the level of the second lumbar vertebra at birth. The objective is to determine the difference between the rates of longitudinal growth of the spinal cord and the spine in human fetuses from the 13th to the 22nd week of gestation (WoG) using magnetic resonance imaging (MRI). Methods: Descriptive observational cross-sectional study of 24 stillbirths (13 ♂, 11 ♀), between the 13th and 22nd WoG, using spinal MRI. We recorded spine and spinal cord lengths in millimeters from the foramen magnum to the coccyx for the former and to the medullary cone for the latter. We identified the position of the medullary cone according to vertebral level and its correlation with the gestational age and the literature. Results: The spinal cord increased in length from 50 to 93 mm, the spine from 57 to 137 mm, and the medullary cone rose from S1 to L2. The rate of growth was 1.2 mm/day for the spine and 0.6 mm/day for the spinal cord. Conclusions: Discordance in the rate of normal longitudinal growth of the spine and spinal cord caused the medullary cone to rise from S1 level to L2 in the second trimester of pregnancy. These results allow an understanding of normal development and certain congenital malformations. Level of evidence IV; Case series.
format Artículo
author Manzone, Patricio
Guidobono, Juan Armando
Forlino, Daniel
author_facet Manzone, Patricio
Guidobono, Juan Armando
Forlino, Daniel
author_sort Manzone, Patricio
title Longitudinal development of the spine and spinal cord in human fetuses
title_short Longitudinal development of the spine and spinal cord in human fetuses
title_full Longitudinal development of the spine and spinal cord in human fetuses
title_fullStr Longitudinal development of the spine and spinal cord in human fetuses
title_full_unstemmed Longitudinal development of the spine and spinal cord in human fetuses
title_sort longitudinal development of the spine and spinal cord in human fetuses
publisher Sociedad Brasileira de Columna
publishDate 2022
url http://repositorio.unne.edu.ar/handle/123456789/48475
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AT forlinodaniel longitudinaldevelopmentofthespineandspinalcordinhumanfetuses
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spelling I48-R184-123456789-484752024-12-16T11:34:37Z Longitudinal development of the spine and spinal cord in human fetuses Desenvolvimiento longitudinal da coluna vertebral e medula espinal em fetos humanos Desarrollo longitudinal de la columna vertebral y médula espinal en fetos humanos Manzone, Patricio Guidobono, Juan Armando Forlino, Daniel Fetal development Spine Spinal cord Desenvolvimento fetal Coluna vertebral Medula espinal Desarrollo fetal Columna vertebral Médula espinal Objective: The spinal cord extends from the foramen magnum to the sacrum in the human fetus at the beginning of the 2nd quarter. However, the medullary cone is located at or above the level of the second lumbar vertebra at birth. The objective is to determine the difference between the rates of longitudinal growth of the spinal cord and the spine in human fetuses from the 13th to the 22nd week of gestation (WoG) using magnetic resonance imaging (MRI). Methods: Descriptive observational cross-sectional study of 24 stillbirths (13 ♂, 11 ♀), between the 13th and 22nd WoG, using spinal MRI. We recorded spine and spinal cord lengths in millimeters from the foramen magnum to the coccyx for the former and to the medullary cone for the latter. We identified the position of the medullary cone according to vertebral level and its correlation with the gestational age and the literature. Results: The spinal cord increased in length from 50 to 93 mm, the spine from 57 to 137 mm, and the medullary cone rose from S1 to L2. The rate of growth was 1.2 mm/day for the spine and 0.6 mm/day for the spinal cord. Conclusions: Discordance in the rate of normal longitudinal growth of the spine and spinal cord caused the medullary cone to rise from S1 level to L2 in the second trimester of pregnancy. These results allow an understanding of normal development and certain congenital malformations. Level of evidence IV; Case series. Objetivo: A medula espinhal (ME) estende-se desde o forame magno até o sacro no feto humano no início do 2º trimestre. No entanto, ao nascimento, o cone medular localiza-se no nível da segunda vértebra lombar ou acima. O objetivo é determinar as diferenças na taxa de crescimento longitudinal da ME e da coluna vertebral (CV) em fetos humanos da 13a à 22a semana de gestação (SG) por meio de ressonância magnética (RM). Métodos: Estudo observacional transversal descritivo em 24 natimortos (13 ♂, 11 ♀), com idades entre 13ª e 22ª SG, por RM da CV. O comprimento da CV e da ME foi registrado em milímetros, desde o forame magno até o cóccix na CV e até o cone na ME. Identificou-se a posição do cone de acordo com o nível vertebral, sua correlação com a idade gestacional e com literatura. Resultados: O comprimento da ME aumentou de 50 para 93 mm, a CV de 57 para 137 mm e o cone medular subiu de S1 para L2. O ritmo de crescimento foi de 1,2 mm/dia para a CV e de 0,6 mm/dia para a ME. Conclusões: A discordância no ritmo do crescimento longitudinal normal da CV e da ME fez com que o cone medular subisse do nível de S1 até L2 no segundo trimestre de gravidez. Os resultados permitem compreender o desenvolvimento normal e certas malformações congênitas. Nível de evidência IV; Série de casos. Objetivo: La médula espinal (ME) se extiende desde el foramen magnum hasta el sacro en el feto humano al inicio del 2º trimestre. Sin embargo, el cono medular se ubica a nivel de la segunda vertebral lumbar o por encima en el momento del nacimiento. El objetivo es determinar las diferencias en el ritmo de crecimiento longitudinal de la ME y columna vertebral (CV) en fetos humanos desde la 13ª hasta la 22ª semana de gestación (SG) mediante resonancia magnética (RM). Métodos: Estudio descriptivo observacional transversal en 24 mortinatos (13 ♂, 11 ♀), con edades entre la 13ª y 22ª SG, mediante RM de CV. Se registró la longitud de CV y ME, en milímetros, desde el foramen mágnum al coxis en la primera y hasta el cono en la segunda. Se identificó la posición del cono según el nivel vertebral y su correlación con edad gestacional y literatura. Resultados: La ME incrementó su longitud de 50 a 93 mm, la CV de 57 a 137 mm y el cono medular ascendió desde S1 hasta L2. El ritmo de crecimiento fue de 1.2 mm/día para la CV y de 0.6 mm/día para la ME. Conclusiones: La discordancia en el ritmo de crecimiento longitudinal normal de la CV y ME determinó que el cono medular ascienda desde el nivel S1 hasta L2 en el segundo trimestre de gestación. Los resultados permiten comprender el desarrollo normal y ciertas malformaciones congénitas. Nivel de evidencia IV, serie de casos. 2022-06-17T14:37:55Z 2022-06-17T14:37:55Z 2020 Artículo Manzone, Patricio, Guidobono, Juan Armando y Forlino, Daniel, 2020. Longitudinal development of the spine and spinal cord in human fetuses. Coluna/Columna. Sao Paulo: Sociedad Brasileira de Columna, vol. 19, no. 1, p. 8-12. e-ISSN 2177-014X. 1808-1851 http://repositorio.unne.edu.ar/handle/123456789/48475 eng openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ application/pdf application/pdf Sociedad Brasileira de Columna Coluna/Columna, 2020, vol. 19, no. 1, p. 8-12.

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