Human papillomavirus detection in Corrientes, Argentina : high prevalence of type 58 and its phylodynamics

Human papillomavirus (HPV) has the highest mortality rate due to cervical cancer in Northeastern Argentina. The aim of this work was to detect and characterize HPV in samples from the Province of Corrientes, Argentina. HPV detection and typing was performed using PCR-RFLP on samples with different c...

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Detalles Bibliográficos
Autores principales: Marín, Héctor Marcelo, Torres, Carolina, Deluca, Gerardo Daniel, Mbayed, Viviana A.
Formato: Artículo
Lenguaje:Inglés
Publicado: Asociación Argentina de Microbiología 2020
Materias:
Hpv-58
Argentina
E6
E7
Phylodynamics
Filodinámica
Acceso en línea:http://repositorio.unne.edu.ar/handle/123456789/1598
Aporte de:
RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) de Universidad Nacional del Nordeste
id I48-R184-123456789-1598
record_format dspace
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-184
collection RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
language Inglés
topic Hpv-58
Argentina
E6
E7
Phylodynamics
Filodinámica
spellingShingle Hpv-58
Argentina
E6
E7
Phylodynamics
Filodinámica
Marín, Héctor Marcelo
Torres, Carolina
Deluca, Gerardo Daniel
Mbayed, Viviana A.
Human papillomavirus detection in Corrientes, Argentina : high prevalence of type 58 and its phylodynamics
topic_facet Hpv-58
Argentina
E6
E7
Phylodynamics
Filodinámica
description Human papillomavirus (HPV) has the highest mortality rate due to cervical cancer in Northeastern Argentina. The aim of this work was to detect and characterize HPV in samples from the Province of Corrientes, Argentina. HPV detection and typing was performed using PCR-RFLP on samples with different cervical lesions (n = 255). Seventeen viruses typified as HPV- 58 were sequenced (E6 and E7 genes) and mutations were analyzed. HPV DNA was detected in 56.1 % of the cervical lesions (143/255). Twenty-two different HPV types were detected. The type most frequently found among the total number of samples and HPV-positive samples was HPV-16 (14.5 % and 25.9 %, respectively), followed by HPV-58 (8.2 %/14.7 %, respectively), which is also considered a high-risk viral type. Increased severity of the cytological status was associated with greater rates of HPV detection and, especially, with the detection of greater rates of high-risk types. In addition, the evolutionary dynamics of the alpha-9 species group and HPV-58 was studied. All HPV-58 viruses reported in this work belonged to lineage A, sublineage A2. The phylodynamic analysis indicated that diversification of main groups within lineage A might have accompanied or preceded human migrations across the globe. Given that the most prevalent viruses found belonged to high-risk HPV types, some concerns might arise about the extent of cross protection of the vaccines against the types not included in their design.
format Artículo
author Marín, Héctor Marcelo
Torres, Carolina
Deluca, Gerardo Daniel
Mbayed, Viviana A.
author_facet Marín, Héctor Marcelo
Torres, Carolina
Deluca, Gerardo Daniel
Mbayed, Viviana A.
author_sort Marín, Héctor Marcelo
title Human papillomavirus detection in Corrientes, Argentina : high prevalence of type 58 and its phylodynamics
title_short Human papillomavirus detection in Corrientes, Argentina : high prevalence of type 58 and its phylodynamics
title_full Human papillomavirus detection in Corrientes, Argentina : high prevalence of type 58 and its phylodynamics
title_fullStr Human papillomavirus detection in Corrientes, Argentina : high prevalence of type 58 and its phylodynamics
title_full_unstemmed Human papillomavirus detection in Corrientes, Argentina : high prevalence of type 58 and its phylodynamics
title_sort human papillomavirus detection in corrientes, argentina : high prevalence of type 58 and its phylodynamics
publisher Asociación Argentina de Microbiología
publishDate 2020
url http://repositorio.unne.edu.ar/handle/123456789/1598
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AT delucagerardodaniel humanpapillomavirusdetectionincorrientesargentinahighprevalenceoftype58anditsphylodynamics
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