Oxidative stress during in vitro maturation of bovine oocytes: a review
In vitro production (IVP) of bovine embryos has become the most widely used reproductive biotechnologies worldwide. Within this system, in vitro maturation (IVM) of oocytes is a critical step, as it involves nuclear, cytoplasmic, and cumulus cell transformations that determine oocyte competence for...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional del Nordeste
2026
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| Acceso en línea: | https://revistas.unne.edu.ar/index.php/vet/article/view/9105 |
| Aporte de: |
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I48-R154-article-9105 |
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ojs |
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Universidad Nacional del Nordeste |
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I-48 |
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R-154 |
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Revistas UNNE - Universidad Nacional del Noroeste (UNNE) |
| language |
Español |
| format |
Artículo revista |
| topic |
oocyte competence in vitro culture competencia ovocitaria cultivo in vitro |
| spellingShingle |
oocyte competence in vitro culture competencia ovocitaria cultivo in vitro Romero Monteleone, Sabrina Itatí Navarro Krilich, Lia Macarena Yostar, Jonatan Dellavalle, Franco Alejandro Capellari, Adriana Ynsaurralde-Rivolta, Amada Eugenia Oxidative stress during in vitro maturation of bovine oocytes: a review |
| topic_facet |
oocyte competence in vitro culture competencia ovocitaria cultivo in vitro |
| author |
Romero Monteleone, Sabrina Itatí Navarro Krilich, Lia Macarena Yostar, Jonatan Dellavalle, Franco Alejandro Capellari, Adriana Ynsaurralde-Rivolta, Amada Eugenia |
| author_facet |
Romero Monteleone, Sabrina Itatí Navarro Krilich, Lia Macarena Yostar, Jonatan Dellavalle, Franco Alejandro Capellari, Adriana Ynsaurralde-Rivolta, Amada Eugenia |
| author_sort |
Romero Monteleone, Sabrina Itatí |
| title |
Oxidative stress during in vitro maturation of bovine oocytes: a review |
| title_short |
Oxidative stress during in vitro maturation of bovine oocytes: a review |
| title_full |
Oxidative stress during in vitro maturation of bovine oocytes: a review |
| title_fullStr |
Oxidative stress during in vitro maturation of bovine oocytes: a review |
| title_full_unstemmed |
Oxidative stress during in vitro maturation of bovine oocytes: a review |
| title_sort |
oxidative stress during in vitro maturation of bovine oocytes: a review |
| description |
In vitro production (IVP) of bovine embryos has become the most widely used reproductive biotechnologies worldwide. Within this system, in vitro maturation (IVM) of oocytes is a critical step, as it involves nuclear, cytoplasmic, and cumulus cell transformations that determine oocyte competence for fertilization and subsequent embryonic development. IVM is highly sensitive to environmental factors such as temperature, pH, oxygen concentration, light exposure, and culture duration, which may induce oxidative stress and compromise cell viability. Excessive production of reactive oxygen species (ROS) damages key cellular structures, including DNA, proteins, and mitochondria, thereby impairing oocyte maturation and embryonic development. Recent studies indicate that prolonged culture and thermal fluctuations can generate a “molecular memory” that reduces oocyte competence, even under otherwise normal conditions. Several strategies have been proposed to overcome these limitations. Supplementation with antioxidants such as cysteamine, L-cysteine, melatonin, epigallocatechin, resveratrol, vitamin C, and omega-3 fatty acids has shown beneficial effects on oocyte maturation and the reduction of oxidative damage, although with variable outcomes. More recently, folic acid has gained attention due to its antioxidant and epigenetic properties, particularly through the inhibition of ferroptosis and the enhancement of oocyte competence. In conclusion, optimizing IVM requires integrating strict control of environmental conditions with targeted antioxidant and molecular strategies tailored to each laboratory to preserve oocyte quality and maximize embryonic developmental potential. |
| publisher |
Universidad Nacional del Nordeste |
| publishDate |
2026 |
| url |
https://revistas.unne.edu.ar/index.php/vet/article/view/9105 |
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I48-R154-article-91052026-02-04T15:47:33Z Oxidative stress during in vitro maturation of bovine oocytes: a review Estrés oxidativo durante la maduración in vitro de ovocitos bovinos: una revisión Romero Monteleone, Sabrina Itatí Navarro Krilich, Lia Macarena Yostar, Jonatan Dellavalle, Franco Alejandro Capellari, Adriana Ynsaurralde-Rivolta, Amada Eugenia oocyte competence in vitro culture competencia ovocitaria cultivo in vitro In vitro production (IVP) of bovine embryos has become the most widely used reproductive biotechnologies worldwide. Within this system, in vitro maturation (IVM) of oocytes is a critical step, as it involves nuclear, cytoplasmic, and cumulus cell transformations that determine oocyte competence for fertilization and subsequent embryonic development. IVM is highly sensitive to environmental factors such as temperature, pH, oxygen concentration, light exposure, and culture duration, which may induce oxidative stress and compromise cell viability. Excessive production of reactive oxygen species (ROS) damages key cellular structures, including DNA, proteins, and mitochondria, thereby impairing oocyte maturation and embryonic development. Recent studies indicate that prolonged culture and thermal fluctuations can generate a “molecular memory” that reduces oocyte competence, even under otherwise normal conditions. Several strategies have been proposed to overcome these limitations. Supplementation with antioxidants such as cysteamine, L-cysteine, melatonin, epigallocatechin, resveratrol, vitamin C, and omega-3 fatty acids has shown beneficial effects on oocyte maturation and the reduction of oxidative damage, although with variable outcomes. More recently, folic acid has gained attention due to its antioxidant and epigenetic properties, particularly through the inhibition of ferroptosis and the enhancement of oocyte competence. In conclusion, optimizing IVM requires integrating strict control of environmental conditions with targeted antioxidant and molecular strategies tailored to each laboratory to preserve oocyte quality and maximize embryonic developmental potential. La producción in vitro (PIV) de embriones bovinos se ha consolidado como la biotecnología reproductiva más difundida a nivel global. Dentro de este sistema, la maduración in vitro (MIV) de ovocitos constituye un punto crítico, ya que durante este proceso ocurren transformaciones nucleares, citoplasmáticas y del cúmulo que determinan la competencia para la fecundación y el desarrollo embrionario. La MIV es altamente sensible a factores ambientales como el tiempo de cultivo, la temperatura, el pH, la concentración de oxígeno, la exposición a la luz, los cuales pueden inducir estrés oxidativo y comprometer la viabilidad celular. La sobreproducción de especies reactivas de oxígeno daña estructuras esenciales como el ADN, las proteínas y las mitocondrias, afectando la maduración y el posterior desarrollo del embrión. Estudios recientes evidencian que el cultivo prolongado y las fluctuaciones térmicas generan una memoria molecular que reduce la competencia ovocitaria, aun en condiciones posteriores normales. Frente a estas limitaciones, se han propuesto diversas estrategias. La suplementación con antioxidantes como cisteamina, L-cisteína, melatonina, epigalocatequina, resveratrol, vitamina C y ácidos grasos omega-3 ha mostrado efectos positivos en la maduración y en la reducción del daño oxidativo, aunque con resultados variables. Más recientemente, el ácido fólico ha cobrado relevancia por sus efectos antioxidantes y epigenéticos, al inhibir la ferroptosis y mejorar la competencia ovocitaria. En conclusión, la optimización de la MIV requiere integrar el control de factores ambientales con estrategias antioxidantes y moleculares adaptadas a cada laboratorio, a fin de preservar la calidad ovocitaria y maximizar el potencial de desarrollo embrionario Universidad Nacional del Nordeste 2026-02-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/vet/article/view/9105 10.30972/vet.3719105 Revista Veterinaria; Vol. 37 (2026); 1-11 Revista Veterinaria; Vol. 37 (2026); 1-11 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/9105/8821 Derechos de autor 2026 Sabrina Itatí Romero Monteleone, Lia Macarena Navarro Krilich, Jonatan Yostar, Franco Alejandro Dellavalle, Adriana Capellari, Amada Eugenia Ynsaurralde-Rivolta https://creativecommons.org/licenses/by-nc/4.0 |