Clinical and histopathological evaluation of the dental pulp and its relationship with pain in patients with total biopulpectomy treatments
Human dental pulp consists of specialized loose connective tissue that is part of the dentin-pulp complex. During an inflammatory process, pulp tissue produces an increase in internal pressure that causes acute pain and histological changes: irreversible pulpitis (IP) can be symptomatic or asymptoma...
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Facultad de Odontología de la Universidad Nacional del Nordeste (FOUNNE)
2025
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| Acceso en línea: | https://revistas.unne.edu.ar/index.php/rfo/article/view/9029 |
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I48-R154-article-9029 |
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| record_format |
ojs |
| institution |
Universidad Nacional del Nordeste |
| institution_str |
I-48 |
| repository_str |
R-154 |
| container_title_str |
Revistas UNNE - Universidad Nacional del Noroeste (UNNE) |
| language |
Español |
| format |
Artículo revista |
| topic |
pulpitis histology inflammation pulpitis histología inflamación pulpite histología inflamação |
| spellingShingle |
pulpitis histology inflammation pulpitis histología inflamación pulpite histología inflamação Galiana, Mariel Beatriz Galiana, Andrea Verónica Lugo de Langhe, Carlos Daniel Montiel, Natalia Belén Zacarías, Rocío Gualdoni, Graciela Mónica Clinical and histopathological evaluation of the dental pulp and its relationship with pain in patients with total biopulpectomy treatments |
| topic_facet |
pulpitis histology inflammation pulpitis histología inflamación pulpite histología inflamação |
| author |
Galiana, Mariel Beatriz Galiana, Andrea Verónica Lugo de Langhe, Carlos Daniel Montiel, Natalia Belén Zacarías, Rocío Gualdoni, Graciela Mónica |
| author_facet |
Galiana, Mariel Beatriz Galiana, Andrea Verónica Lugo de Langhe, Carlos Daniel Montiel, Natalia Belén Zacarías, Rocío Gualdoni, Graciela Mónica |
| author_sort |
Galiana, Mariel Beatriz |
| title |
Clinical and histopathological evaluation of the dental pulp and its relationship with pain in patients with total biopulpectomy treatments |
| title_short |
Clinical and histopathological evaluation of the dental pulp and its relationship with pain in patients with total biopulpectomy treatments |
| title_full |
Clinical and histopathological evaluation of the dental pulp and its relationship with pain in patients with total biopulpectomy treatments |
| title_fullStr |
Clinical and histopathological evaluation of the dental pulp and its relationship with pain in patients with total biopulpectomy treatments |
| title_full_unstemmed |
Clinical and histopathological evaluation of the dental pulp and its relationship with pain in patients with total biopulpectomy treatments |
| title_sort |
clinical and histopathological evaluation of the dental pulp and its relationship with pain in patients with total biopulpectomy treatments |
| description |
Human dental pulp consists of specialized loose connective tissue that is part of the dentin-pulp complex. During an inflammatory process, pulp tissue produces an increase in internal pressure that causes acute pain and histological changes: irreversible pulpitis (IP) can be symptomatic or asymptomatic, and its histopathological characterization allows establishing different inflammatory stages. The objective was to establish the correlation between pre- and postoperative pain and histopathological findings in pulps extracted from patients with a clinical diagnosis of IP. An observational, cross-sectional study was conducted in patients with IP treated at the Endodontic Clinic of FOUNNE. Pain intensity was measured using the Visual Analogue Scale (VAS) before treatment, 1 to 5 days after treatment, and more than 5 days after treatment, through telephone survey. Pulps were processed and categorized by the Histopathology Service (FOUNNE). The degree of inflammation assessed was: Grade 0 (absent), Grade 1 (1–2 histological characteristics [HC]), Grade 2 (3–4 HC), and Grade 3 (5 or more HC). Of the patients treated, 51% presented Grade 2 pulp inflammation, 28% Grade 3, and 20% Grade 1. The most frequent alterations were fibrosis, hyalinization, mild inflammatory infiltrate, calcific nodules and spicules, and atrophy. Preoperative pain between 6 and 9 on the VAS was reported by 47% of patients. At postoperative follow-up, 73% did not present pain, while the remaining 27% did, in mild (2–3) and severe (8–9) ranges, the latter requiring analgesic prescription. The most frequent histopathological characteristics in the pulp tissues studied were fibrosis, hyalinization, and pulp calcifications. The predominant inflammatory grade was Grade 2. A positive correlation was observed between pre- and postoperative pain. Clinical and histopathological findings did not always show a direct correlation. |
| publisher |
Facultad de Odontología de la Universidad Nacional del Nordeste (FOUNNE) |
| publishDate |
2025 |
| url |
https://revistas.unne.edu.ar/index.php/rfo/article/view/9029 |
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I48-R154-article-90292025-12-29T12:20:58Z Clinical and histopathological evaluation of the dental pulp and its relationship with pain in patients with total biopulpectomy treatments Evaluación clínica e histopatológica de la pulpa dental y su relación con el dolor en pacientes con tratamientos de biopulpectomía total Avaliação clínica e histopatológica da polpa dentária e sua relação com a dor em pacientes submetidos a tratamentos de biopulpectomia total Galiana, Mariel Beatriz Galiana, Andrea Verónica Lugo de Langhe, Carlos Daniel Montiel, Natalia Belén Zacarías, Rocío Gualdoni, Graciela Mónica pulpitis histology inflammation pulpitis histología inflamación pulpite histología inflamação Human dental pulp consists of specialized loose connective tissue that is part of the dentin-pulp complex. During an inflammatory process, pulp tissue produces an increase in internal pressure that causes acute pain and histological changes: irreversible pulpitis (IP) can be symptomatic or asymptomatic, and its histopathological characterization allows establishing different inflammatory stages. The objective was to establish the correlation between pre- and postoperative pain and histopathological findings in pulps extracted from patients with a clinical diagnosis of IP. An observational, cross-sectional study was conducted in patients with IP treated at the Endodontic Clinic of FOUNNE. Pain intensity was measured using the Visual Analogue Scale (VAS) before treatment, 1 to 5 days after treatment, and more than 5 days after treatment, through telephone survey. Pulps were processed and categorized by the Histopathology Service (FOUNNE). The degree of inflammation assessed was: Grade 0 (absent), Grade 1 (1–2 histological characteristics [HC]), Grade 2 (3–4 HC), and Grade 3 (5 or more HC). Of the patients treated, 51% presented Grade 2 pulp inflammation, 28% Grade 3, and 20% Grade 1. The most frequent alterations were fibrosis, hyalinization, mild inflammatory infiltrate, calcific nodules and spicules, and atrophy. Preoperative pain between 6 and 9 on the VAS was reported by 47% of patients. At postoperative follow-up, 73% did not present pain, while the remaining 27% did, in mild (2–3) and severe (8–9) ranges, the latter requiring analgesic prescription. The most frequent histopathological characteristics in the pulp tissues studied were fibrosis, hyalinization, and pulp calcifications. The predominant inflammatory grade was Grade 2. A positive correlation was observed between pre- and postoperative pain. Clinical and histopathological findings did not always show a direct correlation. La pulpa dental humana está constituida por un tejido conectivo laxo especializado que forma parte del complejo dentino-pulpar. Ante un proceso inflamatorio, el tejido pulpar produce un aumento de la presión interna que causa dolor agudo y cambios histológicos: la pulpitis irreversible (PI) puede ser sintomática o asintomática y su caracterización histopatológica permite establecer diferentes estadios inflamatorios. El objetivo fue establecer la correlación entre el dolor pre y postoperatorio y los hallazgos histopatológicos, en pulpas extraídas en pacientes con diagnóstico clínico de PI. Se realizó un estudio observacional, transversal, en pacientes con PI, atendidos en la Clínica de Endodoncia de la FOUNNE. La intensidad del dolor se midió mediante la Escala Visual Analógica (EVA): antes del tratamiento, de 1 a 5 días y más de 5 días posteriores al mismo, por encuesta telefónica. Las pulpas fueron procesadas y categorizadas por el Servicio de Histopatología (FOUNNE). El grado de inflamación evaluado fue: Grado 0 (ausente), Grado 1 (1-2 características histológicas CH), Grado 2 (3-4 CH) y Grado 3 (5 o más CH). El 51% de los pacientes atendidos presentaron Grado 2 de inflamación pulpar, el 28% Grado 3 y el 20% Grado 1. Las alteraciones más frecuentes fueron fibrosis, hialinosis, infiltrado inflamatorio leve, nódulos y agujas cálcicas y atrofia. El 47% de los pacientes manifestó dolor preoperatorio entre 6 y 9 según EVA. En el control posoperatorio, el 73% no presentó dolor, mientras que el 27% restante sí, en rangos leves (2–3) y severos (8–9), requiriendo estos últimos, prescripción analgésica. Las características histopatológicas más frecuentes en los tejidos pulpares estudiados fueron fibrosis, hialinosis y calcificaciones pulpares. El grado inflamatorio que predominó fue el Grado 2. Se observó una correlación positiva entre el dolor pre y post operatorio. Los hallazgos clínicos e histopatológicos no siempre presentaron una correlación directa. A polpa dentária humana é composta por tecido conjuntivo frouxo especializado que integra o complexo dentina-polpa. Diante de um processo inflamatório, o tecido pulpar apresenta aumento da pressão interna que causa dor aguda e alterações histológicas. A pulpite irreversível (IP) pode ser sintomática ou assintomática, e sua caracterização histopatológica permite estabelecer diferentes estágios inflamatórios. O objetivo deste estudo foi estabelecer a correlação entre a dor pré e pós-operatória e os achados histopatológicos em polpas extraídas de pacientes com diagnóstico clínico de IP. Realizou-se um estudo observacional transversal com pacientes com IP atendidos na Clínica Endodôntica da FOUNNE. A intensidade da dor foi medida usando a Escala Visual Analógica (EVA): antes do tratamento, 1 a 5 dias e após mais de 5 dias do procedimento, por entrevista telefônica. As polpas foram processadas e categorizadas pelo Serviço de Histopatologia (FOUNNE). O grau inflamatório avaliado foi: Grau 0 (ausente), Grau 1 (1–2 características histológicas (CH), Grau 2 (3–4 CH) e Grau 3 (≥5 CH). Entre os pacientes atendidos, 51% apresentaram Grau 2 de inflamação pulpar, 28% Grau 3 e 20% Grau 1. As alterações mais frequentes foram fibrose, hialinose, infiltrado inflamatório leve, nódulos e agulhas cálcicas e atrofia. Do total, 47% dos pacientes relataram dor pré-operatória entre 6 e 9 de acordo com a EVA. No controle pós-operatório, 73% não apresentaram dor, enquanto 27% relataram dor leve (2–3) ou severa (8–9), sendo estes últimos casos tratados com prescrição analgésica. As características histopatológicas mais frequentes nos tecidos pulpares estudados foram fibrose, hialinose e calcificações pulpares. O grau inflamatório predominante foi o Grau 2. Observou-se correlação positiva entre a dor pré e pós-operatória. Os achados clínicos e histopatológicos nem sempre apresentam correlação direta. Facultad de Odontología de la Universidad Nacional del Nordeste (FOUNNE) 2025-12-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/rfo/article/view/9029 10.30972/rfo.1829029 Revista de la Facultad de Odontología; Vol. 18 Núm. 2 (2025) 2683-7986 1668-7280 spa https://revistas.unne.edu.ar/index.php/rfo/article/view/9029/8764 https://creativecommons.org/licenses/by-nc/4.0 |