Decrease of colonic dysplastic lesions induced by 1,2–dimetylhydrazine in butyric acid supplemented rats

The butyric acid is considered as an anticancerigenous compound in several models of experimental carcinogenesis. It is one of the end products of the non–gaseous fermentation carried out by the microbial anaerobic flora of the mammalian large bowel and rumen. The milk and dairy products are the m...

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Autores principales: Catuogno, M. S., Montenegro, M. A., Sánchez Negrette, M., Ramirez, G. V.
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional del Nordeste 2011
Acceso en línea:https://revistas.unne.edu.ar/index.php/vet/article/view/9
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Revistas UNNE - Universidad Nacional del Noroeste (UNNE) de Universidad Nacional del Nordeste
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language Español
format Artículo revista
author Catuogno, M. S.
Montenegro, M. A.
Sánchez Negrette, M.
Ramirez, G. V.
spellingShingle Catuogno, M. S.
Montenegro, M. A.
Sánchez Negrette, M.
Ramirez, G. V.
Decrease of colonic dysplastic lesions induced by 1,2–dimetylhydrazine in butyric acid supplemented rats
author_facet Catuogno, M. S.
Montenegro, M. A.
Sánchez Negrette, M.
Ramirez, G. V.
author_sort Catuogno, M. S.
title Decrease of colonic dysplastic lesions induced by 1,2–dimetylhydrazine in butyric acid supplemented rats
title_short Decrease of colonic dysplastic lesions induced by 1,2–dimetylhydrazine in butyric acid supplemented rats
title_full Decrease of colonic dysplastic lesions induced by 1,2–dimetylhydrazine in butyric acid supplemented rats
title_fullStr Decrease of colonic dysplastic lesions induced by 1,2–dimetylhydrazine in butyric acid supplemented rats
title_full_unstemmed Decrease of colonic dysplastic lesions induced by 1,2–dimetylhydrazine in butyric acid supplemented rats
title_sort decrease of colonic dysplastic lesions induced by 1,2–dimetylhydrazine in butyric acid supplemented rats
description The butyric acid is considered as an anticancerigenous compound in several models of experimental carcinogenesis. It is one of the end products of the non–gaseous fermentation carried out by the microbial anaerobic flora of the mammalian large bowel and rumen. The milk and dairy products are the main source of butyric acid among the animal products. The aim of this study was to determine the antitumorigenic effect of butyric acid on the development of dysplastic lesions, considered as unequivocal histologic markers of colon cancer in its initial state, in 1,2–dymethylhidrazine–treated rats. Six–week–old Wistar male rats with average body weight of 160 g were used. Butyric acid was administered diluted in drinking water at the dose of 4 mg/ml for 26 weeks. Dysplastic lesions in the large bowel were induced by a weekly subcutaneous injection of 1,2–dymethylhidrazine during 17 and 5 times to respective sub–groups. Less incidence of dysplastic lesions was observed in butyric acid–supplemented groups, both in sub–group with 17 inoculations and in the sub–group with 5 inoculations, compared to control sub–groups (without supplementation). The dysplastic lesions also isplayed variation in the mucin content depending on the severity of the dysplasia. We conclude that the use of butyric acid as an antitumorigenic compound, would be the reason for the marked decrease on the development of precarcinomatous lesions, considered as important precursors of colon carcinomas. Key words: rat, dysplastic lesions, colon cancer, butiric acid, dymethylhidrazine.
publisher Universidad Nacional del Nordeste
publishDate 2011
url https://revistas.unne.edu.ar/index.php/vet/article/view/9
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spelling I48-R154-article-92025-02-12T21:56:28Z Decrease of colonic dysplastic lesions induced by 1,2–dimetylhydrazine in butyric acid supplemented rats Disminución de lesiones displásicas colónicas inducidas por 1,2–dimetilhidrazina en ratas suplementadas con ácido butírico Catuogno, M. S. Montenegro, M. A. Sánchez Negrette, M. Ramirez, G. V. The butyric acid is considered as an anticancerigenous compound in several models of experimental carcinogenesis. It is one of the end products of the non–gaseous fermentation carried out by the microbial anaerobic flora of the mammalian large bowel and rumen. The milk and dairy products are the main source of butyric acid among the animal products. The aim of this study was to determine the antitumorigenic effect of butyric acid on the development of dysplastic lesions, considered as unequivocal histologic markers of colon cancer in its initial state, in 1,2–dymethylhidrazine–treated rats. Six–week–old Wistar male rats with average body weight of 160 g were used. Butyric acid was administered diluted in drinking water at the dose of 4 mg/ml for 26 weeks. Dysplastic lesions in the large bowel were induced by a weekly subcutaneous injection of 1,2–dymethylhidrazine during 17 and 5 times to respective sub–groups. Less incidence of dysplastic lesions was observed in butyric acid–supplemented groups, both in sub–group with 17 inoculations and in the sub–group with 5 inoculations, compared to control sub–groups (without supplementation). The dysplastic lesions also isplayed variation in the mucin content depending on the severity of the dysplasia. We conclude that the use of butyric acid as an antitumorigenic compound, would be the reason for the marked decrease on the development of precarcinomatous lesions, considered as important precursors of colon carcinomas. Key words: rat, dysplastic lesions, colon cancer, butiric acid, dymethylhidrazine. El ácido butírico es considerado como agente anticancerígeno en varios modelos de cáncer experimental. Constituye uno de los productos finales de la fermentación no gaseosa producida por la flora microbiana presente en intestino grueso y rumen de mamíferos. Entre los productos de origen animal, la leche y los productos lácteos constituyen una de las principales fuentes de ácido butírico. Nuestro objetivo fue evaluar el efecto anticancerígeno del acido butírico sobre el desarrollo de lesiones displásicas, consideradas marcadores histológicos de cáncer de colon en sus estadios iniciales, en ratas tratadas con el carcinógeno 1,2–dimetilhidrazina. Fueron utilizadas ratas Wistar, machos con un peso promedio de 160 g a las cuales se les administró ácido butírico puro diluido en el agua de bebida a la concentración de 4 mg/ml, durante 26 semanas. Las lesiones displásicas en el intestino grueso fueron inducidas mediante una inyección subcutánea semanal de 1,2–dimetilhidrazina durante 17 y 5 semanas a los respectivos grupos. En los lotes suplementados con ácido butírico se observó menor incidencia de lesiones displásicas tanto en el grupo tratado con 17 inoculaciones como en el grupo tratado con 5 inoculaciones, comparado con los grupos controles que no recibieron ácido butírico. Las lesiones displásicas también mostraron variación en el contenido de mucina dependiendo de la severidad de la displasia. Concluimos que la utilización de ácido butírico como agente anticancerígeno sería responsable de la marcada disminución del desarrollo de lesiones precarcinomatosas, consideradas como importantes precursores del carcinoma de colon. Palabras clave: rata, lesiones displásicas, cáncer de colon, ácido butírico, dimetilhidrazina. Universidad Nacional del Nordeste 2011-11-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/vet/article/view/9 10.30972/vet.2219 Revista Veterinaria; Vol. 22 Núm. 1 (2011); 13-18 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/9/9 Derechos de autor 2011 M. S. Catuogno, M. A. Montenegro, M. Sánchez Negrette, G. V. Ramirez https://creativecommons.org/licenses/by-nc/4.0

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