Secretory carcinoma versus acinar cell carcinoma: analysis immunohistochemical for the differentiation of microcystic variants
Mammary analogue secretory carcinoma (MASC) is a low-grade malignant salivary gland tumor first described in 2010 by Skálová et al. It shares molecular, microscopic, and immunohistochemical characteristicswith mammary secretory carcinoma. Designated as secretory carcinoma (SC) in the 4th edition of...
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| Autores principales: | , , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Facultad de Odontología de la Universidad Nacional del Nordeste (FOUNNE)
2025
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| Acceso en línea: | https://revistas.unne.edu.ar/index.php/rfo/article/view/8598 |
| Aporte de: |
| Sumario: | Mammary analogue secretory carcinoma (MASC) is a low-grade malignant salivary gland tumor first described in 2010 by Skálová et al. It shares molecular, microscopic, and immunohistochemical characteristicswith mammary secretory carcinoma. Designated as secretory carcinoma (SC) in the 4th edition of the WHOClassification of Head and Neck Tumours (2017), it was previously considered a rare variant of acinic cell carcinoma (ACC) before its discovery. Given that its morphological features often lead to an erroneous diagnosis of ACC, immunohistochemistry is a fundamental tool for differential diagnosis. The objective was to employ a panel of immunohistochemical markers for accurate evaluation. Two SC and four ACC cases located in the parotid gland were studied. Histological sections were stained with H&E, and immunohistochemical expression of S100, GATA-3, DOG1, mammaglobin, and Ki67 was analyzed. Both SC cases exhibited a microcystic pattern and positive immunohistochemical staining for S-100, GATA-3, and mammaglobin, with a Ki67 reaction of ≤15%. All four ACC cases also displayed microcystic features. Immunohistostaining was intensely positive for DOG1 and negative for S-100, GATA-3, and mammaglobin. The Ki67 reaction was ≤15%. As SC is an entity with limited publications in dental literature, it is crucial to understand its histological structure, diagnostic criteria, clinical behavior, and prognosis. Although definitive diagnosis relies on highly specialized molecular studies, these are often unavailable in daily practice. Therefore, immunohistochemical markers are essential for differentiating SC from ACC. |
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