Secretory carcinoma versus acinar cell carcinoma: analysis immunohistochemical for the differentiation of microcystic variants

Mammary analogue secretory carcinoma (MASC) is a low-grade malignant salivary gland tumor first described in 2010 by Skálová et al. It shares molecular, microscopic, and immunohistochemical characteristicswith mammary secretory carcinoma. Designated as secretory carcinoma (SC) in the 4th edition of...

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Autores principales:	Samar Romani, María Elena, Fonseca Acosta, Ismael Bernardo, Ávila Uliarte, Rodolfo Esteban, Ferraris, Luis Ángel, Gómez Rosso, María Araceli, Fernández Calderón, Javier Elías, Mazzeo Strazza, Marcelo Adrián
Formato:	Artículo revista
Lenguaje:	Español
Publicado:	Facultad de Odontología de la Universidad Nacional del Nordeste (FOUNNE) 2025
Materias:	carcinoma acinar cell mammary analogue secretory carcinoma diagnosis differential carcinoma de células acinares carcinoma secretor análogo al mamario diagnóstico diferencial carcinoma secretor análogo ao mamário
Acceso en línea:	https://revistas.unne.edu.ar/index.php/rfo/article/view/8598
Aporte de:	Revistas UNNE - Universidad Nacional del Noroeste (UNNE) de Universidad Nacional del Nordeste

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institution	Universidad Nacional del Nordeste
institution_str	I-48
repository_str	R-154
container_title_str	Revistas UNNE - Universidad Nacional del Noroeste (UNNE)
language	Español
format	Artículo revista
topic	carcinoma acinar cell mammary analogue secretory carcinoma diagnosis differential carcinoma de células acinares carcinoma secretor análogo al mamario diagnóstico diferencial carcinoma de células acinares carcinoma secretor análogo ao mamário diagnóstico diferencial
spellingShingle	carcinoma acinar cell mammary analogue secretory carcinoma diagnosis differential carcinoma de células acinares carcinoma secretor análogo al mamario diagnóstico diferencial carcinoma de células acinares carcinoma secretor análogo ao mamário diagnóstico diferencial Samar Romani, María Elena Fonseca Acosta, Ismael Bernardo Ávila Uliarte, Rodolfo Esteban Ferraris, Luis Ángel Gómez Rosso, María Araceli Fernández Calderón, Javier Elías Mazzeo Strazza, Marcelo Adrián Secretory carcinoma versus acinar cell carcinoma: analysis immunohistochemical for the differentiation of microcystic variants
topic_facet	carcinoma acinar cell mammary analogue secretory carcinoma diagnosis differential carcinoma de células acinares carcinoma secretor análogo al mamario diagnóstico diferencial carcinoma de células acinares carcinoma secretor análogo ao mamário diagnóstico diferencial
author	Samar Romani, María Elena Fonseca Acosta, Ismael Bernardo Ávila Uliarte, Rodolfo Esteban Ferraris, Luis Ángel Gómez Rosso, María Araceli Fernández Calderón, Javier Elías Mazzeo Strazza, Marcelo Adrián
author_facet	Samar Romani, María Elena Fonseca Acosta, Ismael Bernardo Ávila Uliarte, Rodolfo Esteban Ferraris, Luis Ángel Gómez Rosso, María Araceli Fernández Calderón, Javier Elías Mazzeo Strazza, Marcelo Adrián
author_sort	Samar Romani, María Elena
title	Secretory carcinoma versus acinar cell carcinoma: analysis immunohistochemical for the differentiation of microcystic variants
title_short	Secretory carcinoma versus acinar cell carcinoma: analysis immunohistochemical for the differentiation of microcystic variants
title_full	Secretory carcinoma versus acinar cell carcinoma: analysis immunohistochemical for the differentiation of microcystic variants
title_fullStr	Secretory carcinoma versus acinar cell carcinoma: analysis immunohistochemical for the differentiation of microcystic variants
title_full_unstemmed	Secretory carcinoma versus acinar cell carcinoma: analysis immunohistochemical for the differentiation of microcystic variants
title_sort	secretory carcinoma versus acinar cell carcinoma: analysis immunohistochemical for the differentiation of microcystic variants
description	Mammary analogue secretory carcinoma (MASC) is a low-grade malignant salivary gland tumor first described in 2010 by Skálová et al. It shares molecular, microscopic, and immunohistochemical characteristicswith mammary secretory carcinoma. Designated as secretory carcinoma (SC) in the 4th edition of the WHOClassification of Head and Neck Tumours (2017), it was previously considered a rare variant of acinic cell carcinoma (ACC) before its discovery. Given that its morphological features often lead to an erroneous diagnosis of ACC, immunohistochemistry is a fundamental tool for differential diagnosis. The objective was to employ a panel of immunohistochemical markers for accurate evaluation. Two SC and four ACC cases located in the parotid gland were studied. Histological sections were stained with H&E, and immunohistochemical expression of S100, GATA-3, DOG1, mammaglobin, and Ki67 was analyzed. Both SC cases exhibited a microcystic pattern and positive immunohistochemical staining for S-100, GATA-3, and mammaglobin, with a Ki67 reaction of ≤15%. All four ACC cases also displayed microcystic features. Immunohistostaining was intensely positive for DOG1 and negative for S-100, GATA-3, and mammaglobin. The Ki67 reaction was ≤15%. As SC is an entity with limited publications in dental literature, it is crucial to understand its histological structure, diagnostic  criteria, clinical behavior, and prognosis. Although definitive diagnosis relies on highly specialized molecular studies, these are often unavailable in daily practice. Therefore, immunohistochemical markers are essential for differentiating SC from ACC.
publisher	Facultad de Odontología de la Universidad Nacional del Nordeste (FOUNNE)
publishDate	2025
url	https://revistas.unne.edu.ar/index.php/rfo/article/view/8598
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last_indexed	2025-10-17T05:01:25Z
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spelling	I48-R154-article-85982025-08-29T15:10:10Z Secretory carcinoma versus acinar cell carcinoma: analysis immunohistochemical for the differentiation of microcystic variants Carcinoma secretor versus carcinoma de células acinares: análisis inmunohistoquímico para la diferenciación de variantes microquísticas Carcinoma secretor versus carcinoma de células acinares: análise imuno-histoquímica para diferenciação de variantes microcisticas Samar Romani, María Elena Fonseca Acosta, Ismael Bernardo Ávila Uliarte, Rodolfo Esteban Ferraris, Luis Ángel Gómez Rosso, María Araceli Fernández Calderón, Javier Elías Mazzeo Strazza, Marcelo Adrián carcinoma acinar cell mammary analogue secretory carcinoma diagnosis differential carcinoma de células acinares carcinoma secretor análogo al mamario diagnóstico diferencial carcinoma de células acinares carcinoma secretor análogo ao mamário diagnóstico diferencial Mammary analogue secretory carcinoma (MASC) is a low-grade malignant salivary gland tumor first described in 2010 by Skálová et al. It shares molecular, microscopic, and immunohistochemical characteristicswith mammary secretory carcinoma. Designated as secretory carcinoma (SC) in the 4th edition of the WHOClassification of Head and Neck Tumours (2017), it was previously considered a rare variant of acinic cell carcinoma (ACC) before its discovery. Given that its morphological features often lead to an erroneous diagnosis of ACC, immunohistochemistry is a fundamental tool for differential diagnosis. The objective was to employ a panel of immunohistochemical markers for accurate evaluation. Two SC and four ACC cases located in the parotid gland were studied. Histological sections were stained with H&E, and immunohistochemical expression of S100, GATA-3, DOG1, mammaglobin, and Ki67 was analyzed. Both SC cases exhibited a microcystic pattern and positive immunohistochemical staining for S-100, GATA-3, and mammaglobin, with a Ki67 reaction of ≤15%. All four ACC cases also displayed microcystic features. Immunohistostaining was intensely positive for DOG1 and negative for S-100, GATA-3, and mammaglobin. The Ki67 reaction was ≤15%. As SC is an entity with limited publications in dental literature, it is crucial to understand its histological structure, diagnostic  criteria, clinical behavior, and prognosis. Although definitive diagnosis relies on highly specialized molecular studies, these are often unavailable in daily practice. Therefore, immunohistochemical markers are essential for differentiating SC from ACC.  El carcinoma secretor análogo mamario es un tumor de glándulas salivales de baja malignidad descripto en el año 2010 por Skálová et al., con características moleculares, microscópicas e inmunohistoquímicas similares al carcinoma secretor de glándula mamaria. Denominado carcinoma secretor (CS) en la 4º edición de la clasificación de tumores de cabeza y cuello de la OMS (año 2017), antes de su descubrimiento se lo consideraba como una variante rara del carcinoma de células acinares (CCA). Debido a que en muchos casos sus características morfológicas llevan a la evaluación errónea de un CCA la inmunohistoquímica es una herramienta fundamental para su diagnóstico diferencial. Nuestro objetivo fue emplear un panel de marcadores inmunohistoquímicos para su correcta valoración. Se estudiaron 2 CS y 4 CCA localizados en glándula parótida donde se colorearon cortes histológicos con H/E y además se analizó la expresión inmunohistoquímica de S100, GATA-3, DOG1, mamaglobina y KI67. Los 2 casos de CS presentaron un patrón microquístico y marcación inmunohistoquímica positiva para S-100, GATA-3 y mamaglobina y una reacción ≤15% con Ki67. Los cuatro casos de CCA mostraron características microquísticas. La inmunomarcación fue intensamente positiva con DOG1 y negativa con S-100, GATA-3 y mamaglobina. La reacción con Ki67 fue ≤15%. Siendo el CS una entidad poco publicada en la literatura odontológica es importante conocer su estructura histológica, criterios diagnósticos, comportamiento clínico y pronóstico. Si bien el diagnósticodefinitivo es aportado por estudios moleculares altamente especializados, en la práctica diaria no están disponibles y los marcadores inmunohistoquímicos contribuyen a diferenciar el CS del CCA.  O carcinoma secretor análogo mamário é um tumor de glândula salivar de baixo grau de malignidade, descrito em 2010 por Skálová et al., com características moleculares, microscópicas e imuno-histoquímicas semelhantes ao carcinoma secretor da glândula mamária. Denominado carcinoma secretor (CS) na 4ª edição da classificação de tumores de cabeça e pescoço da OMS (2017), antes de sua descoberta era considerada uma variante rara do carcinoma de células acinares (CCA). Como em muitos casos suas características morfológicas levam à avaliação errônea de um CCA, a imuno-histoquímica é um instrumento essencial para o diagnóstico diferencial. Nosso objetivo foi utilizar um painel de marcadores imuno-histoquímicos para sua correta avaliação. Foram estudados 2 CS e 4 CCA localizados na glândula parótida, onde cortes histológicos foram corados com H/E e a expressão imuno-histoquímica de S-100, GATA-3, DOG1, mamaglobina e Ki67 também foi analisada. Os dois casos de SC apresentaram padrão microcístico e imuno-histoquímica positiva para S100, GATA-3 e mamaglobina e reação ≤15% com Ki67. Quatro casos de CCA apresentaram características microcísticas. A imunocoloração foi intensamente positiva com DOG1 e negativa com S-100, GATA-3 e mamaglobina. A reação com Ki67 foi ≤15%. Sendo o carcinoma secretor uma entidade pouco descrita na literatura odontológica, é importante conhecer sua estrutura histológica, critérios diagnósticos, comportamento clínico e prognóstico. Embora o diagnóstico definitivo seja fornecido por estudos moleculares altamente especializados, eles não estão disponíveis na prática diária e os marcadores imuno-histoquímicos contribuem para diferenciar SC de CCA.  Facultad de Odontología de la Universidad Nacional del Nordeste (FOUNNE) 2025-08-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/rfo/article/view/8598 10.30972/rfo.1818598 Revista de la Facultad de Odontología; Vol. 18 Núm. 1 (2025); 18-25 2683-7986 1668-7280 spa https://revistas.unne.edu.ar/index.php/rfo/article/view/8598/8150 https://creativecommons.org/licenses/by-nc/4.0

Secretory carcinoma versus acinar cell carcinoma: analysis immunohistochemical for the differentiation of microcystic variants

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