Bovine leukemia virus: general characteristics, viral prevalence in South America and its impact on animal and human health

Bovine leukemia virus (VLB) is a member of the Retroviridae family and the causative agent of enzootic bovine leukosis (EBL). This disease leads to economic losses in cattle herds and is transmitted horizontally through contact with infected fluids, such as blood, or vertically via in utero transmis...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Brasso, N., Fuentealba, N. A., Bravi, M. E., Panei, C. J.
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional del Nordeste 2025
Materias:
enzootic bovine leukosis
animal health
prevalence
genotype
leucosis enzoótica bovina
sanidad
prevalencia
genotipos
Acceso en línea:https://revistas.unne.edu.ar/index.php/vet/article/view/8087
Aporte de:
Revistas UNNE - Universidad Nacional del Noroeste (UNNE) de Universidad Nacional del Nordeste
id I48-R154-article-8087
record_format ojs
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-154
container_title_str Revistas UNNE - Universidad Nacional del Noroeste (UNNE)
language Español
format Artículo revista
topic enzootic bovine leukosis
animal health
prevalence
genotype
leucosis enzoótica bovina
sanidad
prevalencia
genotipos
spellingShingle enzootic bovine leukosis
animal health
prevalence
genotype
leucosis enzoótica bovina
sanidad
prevalencia
genotipos
Brasso, N.
Fuentealba, N. A.
Bravi, M. E.
Panei, C. J.
Bovine leukemia virus: general characteristics, viral prevalence in South America and its impact on animal and human health
topic_facet enzootic bovine leukosis
animal health
prevalence
genotype
leucosis enzoótica bovina
sanidad
prevalencia
genotipos
author Brasso, N.
Fuentealba, N. A.
Bravi, M. E.
Panei, C. J.
author_facet Brasso, N.
Fuentealba, N. A.
Bravi, M. E.
Panei, C. J.
author_sort Brasso, N.
title Bovine leukemia virus: general characteristics, viral prevalence in South America and its impact on animal and human health
title_short Bovine leukemia virus: general characteristics, viral prevalence in South America and its impact on animal and human health
title_full Bovine leukemia virus: general characteristics, viral prevalence in South America and its impact on animal and human health
title_fullStr Bovine leukemia virus: general characteristics, viral prevalence in South America and its impact on animal and human health
title_full_unstemmed Bovine leukemia virus: general characteristics, viral prevalence in South America and its impact on animal and human health
title_sort bovine leukemia virus: general characteristics, viral prevalence in south america and its impact on animal and human health
description Bovine leukemia virus (VLB) is a member of the Retroviridae family and the causative agent of enzootic bovine leukosis (EBL). This disease leads to economic losses in cattle herds and is transmitted horizontally through contact with infected fluids, such as blood, or vertically via in utero transmission and/or colostrum consumption by newborn calves. For EBL detection, the World Organisation for Animal Health recommends serological tests such as enzyme-linked immunosorbent assay (ELISA) and agar gel immunodiffusion (AGID), as well as polymerase chain reaction (PCR) tests, which detects proviral DNA segments in infected animals. VLB is prevalent in numerous countries, with herd prevalence reaching up to 90% in endemic areas such as Eastern Europe, several Asian countries, and South America. To date, eleven circulating genotypes have been reported worldwide. Recent findings have raised concerns regarding the oncogenic potential of VLB in humans due to the detection of proviral DNA in blood and breast tissue samples with adenocarcinoma. However, the association between VLB infection and tumor development remains inconclusive. Preventive measures, including selective culling, eradication programs, and improved management practices, depend on the regional prevalence of the disease. Although no commercial vaccines are currently available, vaccine development efforts are underway in Argentina. EBL remains one of the most critical bovine diseases in the country, and continuous, systematic research in collaboration with government agencies is essential for implementing sanitary measures aimed at reducing the prevalence of this viral infection.
publisher Universidad Nacional del Nordeste
publishDate 2025
url https://revistas.unne.edu.ar/index.php/vet/article/view/8087
work_keys_str_mv AT brasson bovineleukemiavirusgeneralcharacteristicsviralprevalenceinsouthamericaanditsimpactonanimalandhumanhealth
AT fuentealbana bovineleukemiavirusgeneralcharacteristicsviralprevalenceinsouthamericaanditsimpactonanimalandhumanhealth
AT bravime bovineleukemiavirusgeneralcharacteristicsviralprevalenceinsouthamericaanditsimpactonanimalandhumanhealth
AT paneicj bovineleukemiavirusgeneralcharacteristicsviralprevalenceinsouthamericaanditsimpactonanimalandhumanhealth
AT brasson virusdelaleucemiabovinacaracteristicasgeneralesprevalenciaenamericadelsureimpactoenlasaludanimalyhumana
AT fuentealbana virusdelaleucemiabovinacaracteristicasgeneralesprevalenciaenamericadelsureimpactoenlasaludanimalyhumana
AT bravime virusdelaleucemiabovinacaracteristicasgeneralesprevalenciaenamericadelsureimpactoenlasaludanimalyhumana
AT paneicj virusdelaleucemiabovinacaracteristicasgeneralesprevalenciaenamericadelsureimpactoenlasaludanimalyhumana
first_indexed 2025-05-17T05:10:39Z
last_indexed 2025-05-17T05:10:39Z
_version_ 1832343190851551232
spelling I48-R154-article-80872025-03-06T22:49:11Z Bovine leukemia virus: general characteristics, viral prevalence in South America and its impact on animal and human health Virus de la leucemia bovina: características generales, prevalencia en América del Sur e impacto en la salud animal y humana Brasso, N. Fuentealba, N. A. Bravi, M. E. Panei, C. J. enzootic bovine leukosis animal health prevalence genotype leucosis enzoótica bovina sanidad prevalencia genotipos Bovine leukemia virus (VLB) is a member of the Retroviridae family and the causative agent of enzootic bovine leukosis (EBL). This disease leads to economic losses in cattle herds and is transmitted horizontally through contact with infected fluids, such as blood, or vertically via in utero transmission and/or colostrum consumption by newborn calves. For EBL detection, the World Organisation for Animal Health recommends serological tests such as enzyme-linked immunosorbent assay (ELISA) and agar gel immunodiffusion (AGID), as well as polymerase chain reaction (PCR) tests, which detects proviral DNA segments in infected animals. VLB is prevalent in numerous countries, with herd prevalence reaching up to 90% in endemic areas such as Eastern Europe, several Asian countries, and South America. To date, eleven circulating genotypes have been reported worldwide. Recent findings have raised concerns regarding the oncogenic potential of VLB in humans due to the detection of proviral DNA in blood and breast tissue samples with adenocarcinoma. However, the association between VLB infection and tumor development remains inconclusive. Preventive measures, including selective culling, eradication programs, and improved management practices, depend on the regional prevalence of the disease. Although no commercial vaccines are currently available, vaccine development efforts are underway in Argentina. EBL remains one of the most critical bovine diseases in the country, and continuous, systematic research in collaboration with government agencies is essential for implementing sanitary measures aimed at reducing the prevalence of this viral infection. El virus de la leucemia bovina (VLB), pertenece a la familia Retroviridae y es el agente causal de la leucosis enzoótica bovina (LEB). Esta enfermedad produce grandes pérdidas económicas en los rebaños tanto de manera directa como indirecta. Su transmisión puede ser horizontal, mediante el contacto con fluidos infectados como sangre, o vertical por vía intrauterina y/o por consumo de calostro en los neonatos. Para la detección de la LEB, la Organización Mundial de Salud Animal recomienda la utilización de pruebas serológicas como el inmunoensayo ligado a una enzima (ELISA) y la doble inmunodifusión en gel de agar (IDGA), como también las pruebas de reacción en cadena de la polimerasa (PCR), que detecta un segmento de ADN proviral en el animal infectado. El VLB se encuentra presente en numerosos países, con una prevalencia de hasta el 90% de los rebaños en zonas endémicas como Europa del Este, varios países de Asia y América del Sur. Se reportaron once genotipos del VLB circulantes a nivel mundial. Se encuentra en discusión el potencial oncogénico del virus en humanos debido a la reciente detección de ADN proviral en muestras de sangre y tejido mamario de pacientes con adenocarcinoma. Sin embargo, la relación entre esta virosis y la presencia de tumores aún no es concluyente. La elección de las medidas preventivas para esta enfermedad basadas en selección, eliminación y buenas prácticas de manejo, dependen de la prevalencia de la misma en cada región. A pesar de que no existen vacunas comerciales contra esta enfermedad, las mismas se encuentran en vías de desarrollo en Argentina. La LEB es una de las enfermedades bovinas más importantes en nuestro país, y su estudio continuo y sistemático permite a los organismos oficiales tomar medidas sanitarias con el fin de disminuir la prevalencia de esta virosis. Universidad Nacional del Nordeste 2025-02-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/vet/article/view/8087 10.30972/vet.3618087 Revista Veterinaria; Vol. 36 Núm. 1 (2025); 1-10 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/8087/7621 https://creativecommons.org/licenses/by-nc/4.0

Ejemplares similares