Serum proteinogram evaluation in dogs with monocytic ehrlichiosis in northeastern Argentina
Canine monocytic ehrlichiosis (CME) is a tick-borne infectious disease that triggers an acute inflammatory response in dogs. The aim of this study was to evaluate serum protein profile alterations in dogs with CME, to identify potential biomarkers for diagnosis and disease monitoring. Serum samples...
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| Autores principales: | , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Universidad Nacional del Nordeste
2024
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| Acceso en línea: | https://revistas.unne.edu.ar/index.php/vet/article/view/7867 |
| Aporte de: |
| Sumario: | Canine monocytic ehrlichiosis (CME) is a tick-borne infectious disease that triggers an acute inflammatory response in dogs. The aim of this study was to evaluate serum protein profile alterations in dogs with CME, to identify potential biomarkers for diagnosis and disease monitoring. Serum samples from eight dogs with a confirmed CME diagnosis through polymerase chain reaction was analyzed. The results of the proteinogram revealed significant alterations in protein fractions. Hypoalbuminemia was observed in seven cases, hypogammaglobulinemia in six, hyperalpha-2 globulinemia in seven, and hyperbeta-globulinemia in two cases. These findings suggest a decrease in hepatic protein synthesis, an altered immune response, and an active inflammatory process. Polyclonal hypergammaglobulinemia, identified in two cases, indicate chronic immune system activation. Unlike hypogammaglobulinemia, which was present in six patients, this condition is not a common manifestation of the disease and could be linked to the pathogenic processes of CME, potentiallyincreasing the susceptibility to secondary infections. In conclusion, serum protein profile is a useful tool for evaluating the inflammatory response in CME cases. The observed alterations in protein fractions can serve as biomarkers for disease diagnosis and monitoring. This study provides relevant information for future research aimed at better understanding the disease pathogenesis and developing new diagnostic tools. |
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