Chromosomic breaks and gaps in breast carcinomas of female dog
A cytogenetic study of canine breast carcinomas was performed in order to identify the occurrence of chromosomal abnormalities. Samples of spontaneous canine mammary tumors were submitted for histopathological evaluation and for cytogenetic analysis. Hematoxylin and eosin staining was used for the f...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional del Nordeste
2010
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| Acceso en línea: | https://revistas.unne.edu.ar/index.php/vet/article/view/618 |
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I48-R154-article-6182025-02-12T21:56:55Z Chromosomic breaks and gaps in breast carcinomas of female dog Quiebres y gaps cromosómicos en carcinomas mamarios de hembras caninas Canzoneri, R. Rosciani, A. S. Jorge, L. C. dog mammary tumors cytogenetic fragile sites perra tumores mamarios citogenética sitios frágiles A cytogenetic study of canine breast carcinomas was performed in order to identify the occurrence of chromosomal abnormalities. Samples of spontaneous canine mammary tumors were submitted for histopathological evaluation and for cytogenetic analysis. Hematoxylin and eosin staining was used for the former and conventional Giemsa staining and NOR banding were performed for the latter. Chromosomal breaks and/or gaps affecting autosomes and sex chromosomes were seen in 5 of a total of 14 cases. The percentage of metaphases with abnormal chromosomes was 61%, the average number of metaphase`s chromosomes affected was 1.26, while a media of 1.47 breaks and/or gaps was seen per metaphase. These alterations were observed in complex and simple carcinomas. We propose to include this type of cytogenetic study in addition to routine techniques in order to improve the diagnosis and prognosis prediction Se realizó un estudio citogenético de carcinomas de mama en hembras caninas con el fin de identificar la ocurrencia de anomalías cromosómicas. Las muestras se obtuvieron de neoplasias mamarias espontáneas y fueron sometidas a evaluación histopatológica y análisis citogenético. Para el primero se utilizó la tinción de hematoxilina y eosina y para el segundo la coloración convencional de Giemsa y bandeo NOR. En 5 oportunidades, de un total de 14 casos estudiados, se observaron quiebres y/o gaps afectando autosomas y cromosomas sexuales. La proporción de metafases verificada en cromosomas anormales fue de 61%, el número promedio de cromosomas afectados por metafase fue de 1,26, mientras que la media de quiebres y/o gaps por metafases fue de 1,47. Estas alteraciones se observaron en carcinomas complejos y simples. Se propone incorporar este tipo de estudio citogenético a las técnicas de rutina con el fin de complementar el diagnóstico y pronóstico de la afección Universidad Nacional del Nordeste 2010-10-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/vet/article/view/618 10.30972/vet.212618 Revista Veterinaria; Vol. 21 Núm. 2 (2010); 81-85 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/618/536 Derechos de autor 2010 R. Canzoneri, A. S. Rosciani, L. C. Jorge https://creativecommons.org/licenses/by-nc/4.0 |
| institution |
Universidad Nacional del Nordeste |
| institution_str |
I-48 |
| repository_str |
R-154 |
| container_title_str |
Revistas UNNE - Universidad Nacional del Noroeste (UNNE) |
| language |
Español |
| format |
Artículo revista |
| topic |
dog mammary tumors cytogenetic fragile sites perra tumores mamarios citogenética sitios frágiles |
| spellingShingle |
dog mammary tumors cytogenetic fragile sites perra tumores mamarios citogenética sitios frágiles Canzoneri, R. Rosciani, A. S. Jorge, L. C. Chromosomic breaks and gaps in breast carcinomas of female dog |
| topic_facet |
dog mammary tumors cytogenetic fragile sites perra tumores mamarios citogenética sitios frágiles |
| author |
Canzoneri, R. Rosciani, A. S. Jorge, L. C. |
| author_facet |
Canzoneri, R. Rosciani, A. S. Jorge, L. C. |
| author_sort |
Canzoneri, R. |
| title |
Chromosomic breaks and gaps in breast carcinomas of female dog |
| title_short |
Chromosomic breaks and gaps in breast carcinomas of female dog |
| title_full |
Chromosomic breaks and gaps in breast carcinomas of female dog |
| title_fullStr |
Chromosomic breaks and gaps in breast carcinomas of female dog |
| title_full_unstemmed |
Chromosomic breaks and gaps in breast carcinomas of female dog |
| title_sort |
chromosomic breaks and gaps in breast carcinomas of female dog |
| description |
A cytogenetic study of canine breast carcinomas was performed in order to identify the occurrence of chromosomal abnormalities. Samples of spontaneous canine mammary tumors were submitted for histopathological evaluation and for cytogenetic analysis. Hematoxylin and eosin staining was used for the former and conventional Giemsa staining and NOR banding were performed for the latter. Chromosomal breaks and/or gaps affecting autosomes and sex chromosomes were seen in 5 of a total of 14 cases. The percentage of metaphases with abnormal chromosomes was 61%, the average number of metaphase`s chromosomes affected was 1.26, while a media of 1.47 breaks and/or gaps was seen per metaphase. These alterations were observed in complex and simple carcinomas. We propose to include this type of cytogenetic study in addition to routine techniques in order to improve the diagnosis and prognosis prediction |
| publisher |
Universidad Nacional del Nordeste |
| publishDate |
2010 |
| url |
https://revistas.unne.edu.ar/index.php/vet/article/view/618 |
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AT canzonerir chromosomicbreaksandgapsinbreastcarcinomasoffemaledog AT roscianias chromosomicbreaksandgapsinbreastcarcinomasoffemaledog AT jorgelc chromosomicbreaksandgapsinbreastcarcinomasoffemaledog AT canzonerir quiebresygapscromosomicosencarcinomasmamariosdehembrascaninas AT roscianias quiebresygapscromosomicosencarcinomasmamariosdehembrascaninas AT jorgelc quiebresygapscromosomicosencarcinomasmamariosdehembrascaninas |
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2025-05-17T05:07:31Z |
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2025-05-17T05:07:31Z |
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1832342992990502912 |