Allopurinol and domperidone in the treatment of canine visceral leishmaniosis
In Argentina, human leishmaniosis treatment is regulated by means of the therapeutic scheme suggested by WHO and is provided by the government. The objective of this present work was to evaluate the progression of clinical signs, laboratory values and parasitic load at the beginning and during the p...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional del Nordeste
2020
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| Acceso en línea: | https://revistas.unne.edu.ar/index.php/vet/article/view/4613 |
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I48-R154-article-46132025-02-12T21:59:14Z Allopurinol and domperidone in the treatment of canine visceral leishmaniosis Allopurinol y domperidona en el tratamiento de leishmaniosis visceral canina Llano, E. G. Maidana, H. R. Báez, A. D. Cabrera, W. R. Benítez, J. S. Canines visceral leishmaniasis allopurinol and domperidone parasite charge clinical and laboratory signs Caninos leishmaniosis visceral allopurinol y domperidona carga parasitaria signos clínicos y laboratoriales In Argentina, human leishmaniosis treatment is regulated by means of the therapeutic scheme suggested by WHO and is provided by the government. The objective of this present work was to evaluate the progression of clinical signs, laboratory values and parasitic load at the beginning and during the progression of canine leishmaniasis, using a protocol that combined oral administration of allopurinol and domperidone as an alternative protocol of the standard pharmacological treatment. Ten dogs were admitted at the veterinary school hospital in Corrientes (Argentina), after clinical signs were evaluated. A comprehensive environmental and pharmacological therapeutic protocol was initiated by the combination of allopurinol and domperidone and a medical follow-up with clinical, laboratorial and parasitological parameters controls. All patients demonstrated a fast response to the treatment. The combination of allopurinol and domperidone shows favorable results, as long as adjustments are made according to clinical signs, biochemical profiles and the estimation of parasitic load. Although a higher number of cases as well as trial time are necessary, the results obtained from the protocol used in this assay, may indicate that it is an alternative that can be used in the pharmacological treatment of canine visceral leishmaniasis. Thus, it may be used as a tool for the epidemiological disease control.. El tratamiento de la leishmaniosis humana en Argentina está normatizado con el esquematerapéutico sugerido por la OMS y es suministrado por el estado nacional en forma gratuita. La mayoría de las drogas utilizadas son desaconsejadas en el tratamiento farmacológico de perros afectados por leishmaniosis visceral por la dificultad de acceder al elevado costo y al riesgo de aumentar la generación de cepas resistentes. El presente trabajo tuvo como objetivo evaluar la progresión de los signos clínicos, valores de laboratorio y carga parasitaria, al inicio y durante la administración combinada de allopurinol y domperidona por vía oral, en la Facultad de Veterinaria de Corrientes (Argentina). Se estudiaron 10 pacientes caninos en los cuales se evaluaron los signos clínicos, se efectuó el análisis serológico y se obtuvieron muestras de médula ósea. Se inició un protocolo terapéutico mediante la combinación de ambos fármacos y se efectuó un seguimiento con controles de los parámetros clínicos, laboratoriales y parasitológicos. Todos los pacientes mostraron mejoría clínica al inicio, pero la evolución fue irregular y particular para cada caso, con reclasificaciones de acuerdo a lo sugerido por el grupo Leishvet. Al realizar ajustes de acuerdo a los signos clínicos, perfiles bioquímicos y estimación de la carga parasitaria, la combinación de allopurinol y domperidona mostró resultados favorables a la dosis recomendada. Si bien es necesario una mayor casuística y tiempo de ensayo, los resultados permiten inferir que este protocolo podría constituir una alternativa en el tratamiento farmacológico y en el control epidemiológico de la leishmaniosis visceral canina. Universidad Nacional del Nordeste 2020-12-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/vet/article/view/4613 10.30972/vet.3114613 Revista Veterinaria; Vol. 31 Núm. 1 (2020); 20-27 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/4613/4319 Derechos de autor 2020 E. G. Llano, H. R. Maidana, A. D. Báez, W. R. Cabrera, J. S. Benítez https://creativecommons.org/licenses/by-nc/4.0 |
| institution |
Universidad Nacional del Nordeste |
| institution_str |
I-48 |
| repository_str |
R-154 |
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Revistas UNNE - Universidad Nacional del Noroeste (UNNE) |
| language |
Español |
| format |
Artículo revista |
| topic |
Canines visceral leishmaniasis allopurinol and domperidone parasite charge clinical and laboratory signs Caninos leishmaniosis visceral allopurinol y domperidona carga parasitaria signos clínicos y laboratoriales |
| spellingShingle |
Canines visceral leishmaniasis allopurinol and domperidone parasite charge clinical and laboratory signs Caninos leishmaniosis visceral allopurinol y domperidona carga parasitaria signos clínicos y laboratoriales Llano, E. G. Maidana, H. R. Báez, A. D. Cabrera, W. R. Benítez, J. S. Allopurinol and domperidone in the treatment of canine visceral leishmaniosis |
| topic_facet |
Canines visceral leishmaniasis allopurinol and domperidone parasite charge clinical and laboratory signs Caninos leishmaniosis visceral allopurinol y domperidona carga parasitaria signos clínicos y laboratoriales |
| author |
Llano, E. G. Maidana, H. R. Báez, A. D. Cabrera, W. R. Benítez, J. S. |
| author_facet |
Llano, E. G. Maidana, H. R. Báez, A. D. Cabrera, W. R. Benítez, J. S. |
| author_sort |
Llano, E. G. |
| title |
Allopurinol and domperidone in the treatment of canine visceral leishmaniosis |
| title_short |
Allopurinol and domperidone in the treatment of canine visceral leishmaniosis |
| title_full |
Allopurinol and domperidone in the treatment of canine visceral leishmaniosis |
| title_fullStr |
Allopurinol and domperidone in the treatment of canine visceral leishmaniosis |
| title_full_unstemmed |
Allopurinol and domperidone in the treatment of canine visceral leishmaniosis |
| title_sort |
allopurinol and domperidone in the treatment of canine visceral leishmaniosis |
| description |
In Argentina, human leishmaniosis treatment is regulated by means of the therapeutic scheme suggested by WHO and is provided by the government. The objective of this present work was to evaluate the progression of clinical signs, laboratory values and parasitic load at the beginning and during the progression of canine leishmaniasis, using a protocol that combined oral administration of allopurinol and domperidone as an alternative protocol of the standard pharmacological treatment. Ten dogs were admitted at the veterinary school hospital in Corrientes (Argentina), after clinical signs were evaluated. A comprehensive environmental and pharmacological therapeutic protocol was initiated by the combination of allopurinol and domperidone and a medical follow-up with clinical, laboratorial and parasitological parameters controls. All patients demonstrated a fast response to the treatment. The combination of allopurinol and domperidone shows favorable results, as long as adjustments are made according to clinical signs, biochemical profiles and the estimation of parasitic load. Although a higher number of cases as well as trial time are necessary, the results obtained from the protocol used in this assay, may indicate that it is an alternative that can be used in the pharmacological treatment of canine visceral leishmaniasis. Thus, it may be used as a tool for the epidemiological disease control.. |
| publisher |
Universidad Nacional del Nordeste |
| publishDate |
2020 |
| url |
https://revistas.unne.edu.ar/index.php/vet/article/view/4613 |
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