Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity
The comparative antidepressant activity of the extracts of Hypericum perforatum and Rosmarinus officinalis using animal models of depression were evaluated. The herbal extracts of Hypericum perforatum (20 mg/kg/p.o.), Rosmarinus officinalis (500 mg/kg/p.o.) were subjected for its antidepressant acti...
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Autores principales: | , , , |
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Formato: | Articulo Comunicacion |
Lenguaje: | Inglés |
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2011
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8256 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_9.pdf |
Aporte de: |
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I19-R120-10915-8256 |
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institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Farmacia antidepressant activity; Hypericum perforatum; Rosmarinus officinalis Extractos Vegetales Agentes Antidepresivos |
spellingShingle |
Farmacia antidepressant activity; Hypericum perforatum; Rosmarinus officinalis Extractos Vegetales Agentes Antidepresivos Devi, Kshama Satish, Hanumantharayashetty Khajuria, Deepak Kumar Moinuddin, Ghulam Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity |
topic_facet |
Farmacia antidepressant activity; Hypericum perforatum; Rosmarinus officinalis Extractos Vegetales Agentes Antidepresivos |
description |
The comparative antidepressant activity of the extracts of Hypericum perforatum and Rosmarinus officinalis using animal models of depression were evaluated. The herbal extracts of Hypericum perforatum (20 mg/kg/p.o.), Rosmarinus officinalis (500 mg/kg/p.o.) were subjected for its antidepressant activity using four different animal models of depression, viz: Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST) in male Wistar rats. The study after single oral administration of Hypericum perforatum and Rosmarinus officinalis extracts revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to control respectively. However, there was no significant potentiation of PST. The results of our study demonstrate the extracts of Hypericum perforatum and Rosmarinus officinalis proved to have a promising antidepressant potential. |
format |
Articulo Comunicacion |
author |
Devi, Kshama Satish, Hanumantharayashetty Khajuria, Deepak Kumar Moinuddin, Ghulam |
author_facet |
Devi, Kshama Satish, Hanumantharayashetty Khajuria, Deepak Kumar Moinuddin, Ghulam |
author_sort |
Devi, Kshama |
title |
Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity |
title_short |
Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity |
title_full |
Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity |
title_fullStr |
Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity |
title_full_unstemmed |
Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity |
title_sort |
comparative pharmacological evaluation of hypericum perforatum and rosmarinus officinalis for anti-depressant activity |
publishDate |
2011 |
url |
http://sedici.unlp.edu.ar/handle/10915/8256 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_9.pdf |
work_keys_str_mv |
AT devikshama comparativepharmacologicalevaluationofhypericumperforatumandrosmarinusofficinalisforantidepressantactivity AT satishhanumantharayashetty comparativepharmacologicalevaluationofhypericumperforatumandrosmarinusofficinalisforantidepressantactivity AT khajuriadeepakkumar comparativepharmacologicalevaluationofhypericumperforatumandrosmarinusofficinalisforantidepressantactivity AT moinuddinghulam comparativepharmacologicalevaluationofhypericumperforatumandrosmarinusofficinalisforantidepressantactivity |
bdutipo_str |
Repositorios |
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1764820488401453056 |