Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity

The comparative antidepressant activity of the extracts of Hypericum perforatum and Rosmarinus officinalis using animal models of depression were evaluated. The herbal extracts of Hypericum perforatum (20 mg/kg/p.o.), Rosmarinus officinalis (500 mg/kg/p.o.) were subjected for its antidepressant acti...

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Autores principales: Devi, Kshama, Satish, Hanumantharayashetty, Khajuria, Deepak Kumar, Moinuddin, Ghulam
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
antidepressant activity; Hypericum perforatum; Rosmarinus officinalis
Extractos Vegetales
Agentes Antidepresivos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8256
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_9.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8256
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
antidepressant activity; Hypericum perforatum; Rosmarinus officinalis
Extractos Vegetales
Agentes Antidepresivos
spellingShingle Farmacia
antidepressant activity; Hypericum perforatum; Rosmarinus officinalis
Extractos Vegetales
Agentes Antidepresivos
Devi, Kshama
Satish, Hanumantharayashetty
Khajuria, Deepak Kumar
Moinuddin, Ghulam
Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity
topic_facet Farmacia
antidepressant activity; Hypericum perforatum; Rosmarinus officinalis
Extractos Vegetales
Agentes Antidepresivos
description The comparative antidepressant activity of the extracts of Hypericum perforatum and Rosmarinus officinalis using animal models of depression were evaluated. The herbal extracts of Hypericum perforatum (20 mg/kg/p.o.), Rosmarinus officinalis (500 mg/kg/p.o.) were subjected for its antidepressant activity using four different animal models of depression, viz: Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST) in male Wistar rats. The study after single oral administration of Hypericum perforatum and Rosmarinus officinalis extracts revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to control respectively. However, there was no significant potentiation of PST. The results of our study demonstrate the extracts of Hypericum perforatum and Rosmarinus officinalis proved to have a promising antidepressant potential.
format Articulo
Comunicacion
author Devi, Kshama
Satish, Hanumantharayashetty
Khajuria, Deepak Kumar
Moinuddin, Ghulam
author_facet Devi, Kshama
Satish, Hanumantharayashetty
Khajuria, Deepak Kumar
Moinuddin, Ghulam
author_sort Devi, Kshama
title Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity
title_short Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity
title_full Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity
title_fullStr Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity
title_full_unstemmed Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity
title_sort comparative pharmacological evaluation of hypericum perforatum and rosmarinus officinalis for anti-depressant activity
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8256
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_9.pdf
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AT khajuriadeepakkumar comparativepharmacologicalevaluationofhypericumperforatumandrosmarinusofficinalisforantidepressantactivity
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