Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays

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The aim of this work was to analyse the hypotensive effect of amaranth protein/peptides on spontaneously hypertensive rats (SHR). The mechanism of action of these peptides was studied in vivo and ex vivo. We also tested the effect of protection against gastrointestinal digestion (GID) exerted by an...

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Autores principales: Suárez, Santiago Emmanuel, Aphalo, Paula, Rinaldi, Gustavo, Añón, María Cristina, Quiroga, Alejandra Viviana
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Ciencias Exactas
Amaranth proteins
Antihypertensive activity
Protein hydrolysate
Spontaneously hypertensive rats
Renin-angiotensin system
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/151446
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-151446
record_format dspace
spelling I19-R120-10915-1514462023-04-13T20:40:22Z http://sedici.unlp.edu.ar/handle/10915/151446 issn:0308-8146 Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays Suárez, Santiago Emmanuel Aphalo, Paula Rinaldi, Gustavo Añón, María Cristina Quiroga, Alejandra Viviana 2020 2023-04-13T18:14:59Z en Ciencias Exactas Amaranth proteins Antihypertensive activity Protein hydrolysate Spontaneously hypertensive rats Renin-angiotensin system The aim of this work was to analyse the hypotensive effect of amaranth protein/peptides on spontaneously hypertensive rats (SHR). The mechanism of action of these peptides was studied in vivo and ex vivo. We also tested the effect of protection against gastrointestinal digestion (GID) exerted by an O:W emulsion on the integrity of the antihypertensive peptides. All samples tested produced a decrease in blood pressure (SBP). The animals treated with emulsion (GE) and emulsion+peptide (GE+VIKP) showed the most significant reduction in the SBP (42 ± 2 mmHg and 35 ± 2 mmHg, respectively). The results presented suggest that after GID, a variety of peptides with biological activities were released or were resistant to this process. These peptides play a role in the regulation of the SBP by acting on plasma ACE, plasma renin and the vascular system. These results support the use of amaranth protein/peptides in the elaboration of functional foods for hypertensive individuals. Centro de Investigación y Desarrollo en Criotecnología de Alimentos Facultad de Ciencias Médicas Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Amaranth proteins
Antihypertensive activity
Protein hydrolysate
Spontaneously hypertensive rats
Renin-angiotensin system
spellingShingle Ciencias Exactas
Amaranth proteins
Antihypertensive activity
Protein hydrolysate
Spontaneously hypertensive rats
Renin-angiotensin system
Suárez, Santiago Emmanuel
Aphalo, Paula
Rinaldi, Gustavo
Añón, María Cristina
Quiroga, Alejandra Viviana
Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
topic_facet Ciencias Exactas
Amaranth proteins
Antihypertensive activity
Protein hydrolysate
Spontaneously hypertensive rats
Renin-angiotensin system
description The aim of this work was to analyse the hypotensive effect of amaranth protein/peptides on spontaneously hypertensive rats (SHR). The mechanism of action of these peptides was studied in vivo and ex vivo. We also tested the effect of protection against gastrointestinal digestion (GID) exerted by an O:W emulsion on the integrity of the antihypertensive peptides. All samples tested produced a decrease in blood pressure (SBP). The animals treated with emulsion (GE) and emulsion+peptide (GE+VIKP) showed the most significant reduction in the SBP (42 ± 2 mmHg and 35 ± 2 mmHg, respectively). The results presented suggest that after GID, a variety of peptides with biological activities were released or were resistant to this process. These peptides play a role in the regulation of the SBP by acting on plasma ACE, plasma renin and the vascular system. These results support the use of amaranth protein/peptides in the elaboration of functional foods for hypertensive individuals.
format Articulo
Articulo
author Suárez, Santiago Emmanuel
Aphalo, Paula
Rinaldi, Gustavo
Añón, María Cristina
Quiroga, Alejandra Viviana
author_facet Suárez, Santiago Emmanuel
Aphalo, Paula
Rinaldi, Gustavo
Añón, María Cristina
Quiroga, Alejandra Viviana
author_sort Suárez, Santiago Emmanuel
title Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
title_short Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
title_full Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
title_fullStr Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
title_full_unstemmed Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
title_sort effect of amaranth proteins on the ras system : in vitro, in vivo and ex vivo assays
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/151446
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