Antithrombotic Effects of Amaranthus hypochondriacus Proteins in Rats

Cardiovascular disease (CVD) is a major cause of disability and premature death throughout the world. Diets with antithrombotic components offer a convenient and effective way of preventing and reducing CVD incidence. The aim of the present work was to assess in vivo and ...

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Detalles Bibliográficos
Autores principales:	Sabbione, Ana Clara, Rinaldi, Gustavo, Añón, María Cristina, Scilingo, Adriana Alicia
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2016
Materias:	Ciencias Exactas Ciencias Médicas Functional food Amaranth proteins Antithrombotic activity Animals assays
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/145015
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-145015
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Exactas Ciencias Médicas Functional food Amaranth proteins Antithrombotic activity Animals assays
spellingShingle	Ciencias Exactas Ciencias Médicas Functional food Amaranth proteins Antithrombotic activity Animals assays Sabbione, Ana Clara Rinaldi, Gustavo Añón, María Cristina Scilingo, Adriana Alicia Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
topic_facet	Ciencias Exactas Ciencias Médicas Functional food Amaranth proteins Antithrombotic activity Animals assays
description	Cardiovascular disease (CVD) is a major cause of disability and premature death throughout the world. Diets with antithrombotic components offer a convenient and effective way of preventing and reducing CVD incidence. The aim of the present work was to assess <i>in vivo</i> and <i>ex vivo</i> effects of <i>Amaranthus hypochondriacus</i> proteins on platelet plug formation and coagulation cascade. Amaranth proteins were orally administrated to rats (AG, 8 animals) and bleeding time was determined showing no significant difference compared with control rats (CG, 7 animals). However, results show a strong tendency, suggesting that amaranth proteins are involved in the inhibition of thrombus formation. Non-anticoagulated blood extracted from animals was analyzed with the hemostatometer, where AG parameters obtained were twice the values showed by CG. The clotting tests, thrombin time (TT) and activated partial thromboplastin time (APTT), presented a 17 and 14% clotting formation increase respectively when comparing AG with CG. The <i>ex-vivo</i> assays confirm the hypothesis inferring that amaranth proteins are a potential antithrombotic agent.
format	Articulo Articulo
author	Sabbione, Ana Clara Rinaldi, Gustavo Añón, María Cristina Scilingo, Adriana Alicia
author_facet	Sabbione, Ana Clara Rinaldi, Gustavo Añón, María Cristina Scilingo, Adriana Alicia
author_sort	Sabbione, Ana Clara
title	Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
title_short	Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
title_full	Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
title_fullStr	Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
title_full_unstemmed	Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
title_sort	antithrombotic effects of <i>amaranthus hypochondriacus</i> proteins in rats
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/145015
work_keys_str_mv	AT sabbioneanaclara antithromboticeffectsofiamaranthushypochondriacusiproteinsinrats AT rinaldigustavo antithromboticeffectsofiamaranthushypochondriacusiproteinsinrats AT anonmariacristina antithromboticeffectsofiamaranthushypochondriacusiproteinsinrats AT scilingoadrianaalicia antithromboticeffectsofiamaranthushypochondriacusiproteinsinrats
bdutipo_str	Repositorios
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Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats

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