Vitamin A supplementation inhibits chemiluminescence and lipid peroxidation in isolated rat liver microsomes and mitochondria

In the present study we investigated if administration of vitamin A could protect rat liver microsomes and mitochondria from in vitro peroxidation. Appreciable decrease of chemiluminescence and lipid peroxidation was measured in microsomal membranes from rats receiving vitamin A, with respect to con...

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Autores principales: Palacios, Alejandro, Piergiacomi, Viviana Angélica, Catalá, Ángel
Formato: Articulo
Lenguaje:Inglés
Publicado: 1996
Materias:
Ciencias Veterinarias
Vitamin A
rat liver
microsomes
mitochondria
peroxidation chemiluminescence
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/134095
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-134095
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Vitamin A
rat liver
microsomes
mitochondria
peroxidation chemiluminescence
spellingShingle Ciencias Veterinarias
Vitamin A
rat liver
microsomes
mitochondria
peroxidation chemiluminescence
Palacios, Alejandro
Piergiacomi, Viviana Angélica
Catalá, Ángel
Vitamin A supplementation inhibits chemiluminescence and lipid peroxidation in isolated rat liver microsomes and mitochondria
topic_facet Ciencias Veterinarias
Vitamin A
rat liver
microsomes
mitochondria
peroxidation chemiluminescence
description In the present study we investigated if administration of vitamin A could protect rat liver microsomes and mitochondria from in vitro peroxidation. Appreciable decrease of chemiluminescence and lipid peroxidation was measured in microsomal membranes from rats receiving vitamin A, with respect to control animals. In membranes derived from control animals, the fatty acid composition was profoundly modified when subjected to in vitro peroxidation mediated by ascorbate-Fe++, with a considerable decrease of 20:4 n6 and 22:6 n3 in mitochondria and 18:2 n6 and 20:4 n6 in microsomes. As a consequence the peroxidizability index, a parameter based on the maximal rate of oxidation of specific fatty acids was higher in supplemented animals than in control group when both kind of membranes were analyzed. These changes were less pronounced in membranes derived from rats receiving vitamin A. These results are in agreement with previous results that indicated that vitamin A may act as an antioxidant protecting membranes from deleterious effects.
format Articulo
Articulo
author Palacios, Alejandro
Piergiacomi, Viviana Angélica
Catalá, Ángel
author_facet Palacios, Alejandro
Piergiacomi, Viviana Angélica
Catalá, Ángel
author_sort Palacios, Alejandro
title Vitamin A supplementation inhibits chemiluminescence and lipid peroxidation in isolated rat liver microsomes and mitochondria
title_short Vitamin A supplementation inhibits chemiluminescence and lipid peroxidation in isolated rat liver microsomes and mitochondria
title_full Vitamin A supplementation inhibits chemiluminescence and lipid peroxidation in isolated rat liver microsomes and mitochondria
title_fullStr Vitamin A supplementation inhibits chemiluminescence and lipid peroxidation in isolated rat liver microsomes and mitochondria
title_full_unstemmed Vitamin A supplementation inhibits chemiluminescence and lipid peroxidation in isolated rat liver microsomes and mitochondria
title_sort vitamin a supplementation inhibits chemiluminescence and lipid peroxidation in isolated rat liver microsomes and mitochondria
publishDate 1996
url http://sedici.unlp.edu.ar/handle/10915/134095
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AT piergiacomivivianaangelica vitaminasupplementationinhibitschemiluminescenceandlipidperoxidationinisolatedratlivermicrosomesandmitochondria
AT catalaangel vitaminasupplementationinhibitschemiluminescenceandlipidperoxidationinisolatedratlivermicrosomesandmitochondria
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