Antithrombotic and Antioxidant Activity of Amaranth Hydrolysate Obtained by Activation of an Endogenous Protease

Ingestion of diets with antithrombotic and antioxidant components offer a convenient and effective way to prevent and reduce the incidence of cardiovascular diseases. The aim of the present work was to obtain an amaranth hydrolysate by the activation of an endogenous aspartic protease, to establish...

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Autores principales:	Sabbione, Ana Clara, Ibañez, Sabrina Magalí, Martínez, Estela Nora, Añón, María Cristina, Scilingo, Adriana Alicia
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2016
Materias:	Ciencias Exactas Amaranth proteins Endogenous aspartic protease Bioactive peptides Antithrombotic and antioxidant activity
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/131192
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-131192
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Exactas Amaranth proteins Endogenous aspartic protease Bioactive peptides Antithrombotic and antioxidant activity
spellingShingle	Ciencias Exactas Amaranth proteins Endogenous aspartic protease Bioactive peptides Antithrombotic and antioxidant activity Sabbione, Ana Clara Ibañez, Sabrina Magalí Martínez, Estela Nora Añón, María Cristina Scilingo, Adriana Alicia Antithrombotic and Antioxidant Activity of Amaranth Hydrolysate Obtained by Activation of an Endogenous Protease
topic_facet	Ciencias Exactas Amaranth proteins Endogenous aspartic protease Bioactive peptides Antithrombotic and antioxidant activity
description	Ingestion of diets with antithrombotic and antioxidant components offer a convenient and effective way to prevent and reduce the incidence of cardiovascular diseases. The aim of the present work was to obtain an amaranth hydrolysate by the activation of an endogenous aspartic protease, to establish adequate experimental conditions, and to evaluate its antithrombotic and antioxidant activity in order to assess its potential application as an ingredient in functional foods. The results obtained not only confirmed the presence of an endogenous protease in the amaranth isolate, but also allowed us to select an adequate incubation conditions (pH 2, 40 °C, 16 h). The hydrolysate obtained (degree of hydrolysis 5.3 ± 0.4 %) showed potential antithrombotic activity (IC₅₀ = 5.9 ± 0.1 mg soluble protein/mL) and had more antioxidant activity than the isolate, indicating that the activation of the protease released bioactive peptides from amaranth proteins. Decreasing the pH is a simple and cheap process and is another way to obtain potential functional ingredients with bioactive compounds.
format	Articulo Articulo
author	Sabbione, Ana Clara Ibañez, Sabrina Magalí Martínez, Estela Nora Añón, María Cristina Scilingo, Adriana Alicia
author_facet	Sabbione, Ana Clara Ibañez, Sabrina Magalí Martínez, Estela Nora Añón, María Cristina Scilingo, Adriana Alicia
author_sort	Sabbione, Ana Clara
title	Antithrombotic and Antioxidant Activity of Amaranth Hydrolysate Obtained by Activation of an Endogenous Protease
title_short	Antithrombotic and Antioxidant Activity of Amaranth Hydrolysate Obtained by Activation of an Endogenous Protease
title_full	Antithrombotic and Antioxidant Activity of Amaranth Hydrolysate Obtained by Activation of an Endogenous Protease
title_fullStr	Antithrombotic and Antioxidant Activity of Amaranth Hydrolysate Obtained by Activation of an Endogenous Protease
title_full_unstemmed	Antithrombotic and Antioxidant Activity of Amaranth Hydrolysate Obtained by Activation of an Endogenous Protease
title_sort	antithrombotic and antioxidant activity of amaranth hydrolysate obtained by activation of an endogenous protease
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/131192
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bdutipo_str	Repositorios
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Antithrombotic and Antioxidant Activity of Amaranth Hydrolysate Obtained by Activation of an Endogenous Protease

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