Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment

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Polyphenols provide by diet may act as antioxidant in the Central Nervous System and exert a protective effect on metabolic diseases. The aim of this study was to establish tea extract effects on oxidative status and murine overweight in accordance with polyphenolic availability in different encepha...

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Autores principales: Miranda, Agustin Ramiro, Cittadini, Maria Cecilia, Albrecht, Claudia, Soria, Elio Andrés
Formato: Artículo revista
Lenguaje:Inglés
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017
Materias:
Central nervous system
Aspidosperma quebracho-blanco
Ilex paraguariensis
Lantana grisebachii
Obesity
Infusion
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/14815
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
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record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Inglés
format Artículo revista
topic Central nervous system
Aspidosperma quebracho-blanco
Ilex paraguariensis
Lantana grisebachii
Obesity
Infusion
spellingShingle Central nervous system
Aspidosperma quebracho-blanco
Ilex paraguariensis
Lantana grisebachii
Obesity
Infusion
Miranda, Agustin Ramiro
Cittadini, Maria Cecilia
Albrecht, Claudia
Soria, Elio Andrés
Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
topic_facet Central nervous system
Aspidosperma quebracho-blanco
Ilex paraguariensis
Lantana grisebachii
Obesity
Infusion
author Miranda, Agustin Ramiro
Cittadini, Maria Cecilia
Albrecht, Claudia
Soria, Elio Andrés
author_facet Miranda, Agustin Ramiro
Cittadini, Maria Cecilia
Albrecht, Claudia
Soria, Elio Andrés
author_sort Miranda, Agustin Ramiro
title Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
title_short Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
title_full Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
title_fullStr Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
title_full_unstemmed Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
title_sort regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
description Polyphenols provide by diet may act as antioxidant in the Central Nervous System and exert a protective effect on metabolic diseases. The aim of this study was to establish tea extract effects on oxidative status and murine overweight in accordance with polyphenolic availability in different encephalic regions. Methods: Balb/c mice (female, n>3) with overweight received for 15 days 100 mg/Kg/d of extract from Lantana grisebachii, Aspidosperma quebracho-blanco, or Ilex paraguariensis extracts and control group (received water without extract). Body weight gain was recorded regularly. Polyphenols, hydroperoxides (HP), lipid peroxides (LP), and superoxide anion (SO) were measured in brain (telencephalon and diencephalon), midbrain, brainstem and cerebellum. Results were compared by ANOVA followed by the Tukey test (P<0.05). Results: A. quebracho-blanco-based treatment decreased weight gain and increased polyphenols in brainstem (p<0.02), although it concomitantly increased SO and LP in this region (p=0.0029 and p=0.0280, respectively). L. grisebachii-based treatment reduced oxidative markers differentially in each region (p<0.05). I. paraguariensis-based treatment oxidized midbrain and cerebellum, although it was antioxidant in the brainstem (p<0.05). All treatments were antioxidant in telencephalon (p=0.0029). Conclusions: The A. quebracho-blanco extract was active on overweight and increased polyphenols in brainstem, with safe functional derivatives being required to avoid oxidative stress. Other extracts affected oxidative status in a region-dependent manner.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2017
url https://revistas.unc.edu.ar/index.php/med/article/view/14815
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