Pituitary tumors: Cell type-specific roles for BMP-4
BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 11706caa a22014177a 4500 | ||
|---|---|---|---|
| 001 | PAPER-7677 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203726.0 | ||
| 008 | 190411s2010 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-77955332616 | |
| 024 | 7 | |2 cas |a Smad protein, 62395-38-4; bromocriptine, 25614-03-3; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; cyclic AMP, 60-92-4; estradiol, 50-28-2; growth hormone releasing factor, 83930-13-6, 9034-39-3; octreotide, 83150-76-9; pasireotide, 396091-73-9; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; Adrenocorticotropic Hormone, 9002-60-2; BMP4 protein, human; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Prolactin, 9002-62-4 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MCEND | ||
| 100 | 1 | |a Labeur, M. | |
| 245 | 1 | 0 | |a Pituitary tumors: Cell type-specific roles for BMP-4 |
| 260 | |c 2010 | ||
| 270 | 1 | 0 | |m Stalla, G.K.; Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804 Munich, Germany; email: stalla@mpipsykl.mpg.de |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Tsukamoto, N., Otsuka, F., Miyoshi, T., Yamanaka, R., Inagaki, K., Yamashita, M., Otani, H., Makino, H., Effects of bone morphogenetic protein (BMP) on adrenocorticotropin production by pituitary corticotrope cells: involvement of up-regulation of BMP receptor signaling by somatostatin analogs (2010) Endocrinology, 151, pp. 1129-1141 | ||
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| 504 | |a Wrana, J.L., Regulation of Smad activity (2000) Cell, 100, pp. 189-192 | ||
| 520 | 3 | |a BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHβ subunit gene transcription in the murine gonadotroph cell line, LβT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid. © 2010 Elsevier Ireland Ltd. |l eng | |
| 593 | |a Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804 Munich, Germany | ||
| 593 | |a Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Biología Molecular y Celular, FCEN, Universidad de Buenos Aires and CONICET, C1428EHA Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ACTH |
| 690 | 1 | 0 | |a BMP-4 |
| 690 | 1 | 0 | |a PITUITARY TUMORS |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a RETINOIC ACID |
| 690 | 1 | 0 | |a TGF-Β |
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEIN 4 |
| 690 | 1 | 0 | |a BROMOCRIPTINE |
| 690 | 1 | 0 | |a CORTICOTROPIN |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a ESTROGEN |
| 690 | 1 | 0 | |a GROWTH HORMONE RELEASING FACTOR |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a OCTREOTIDE |
| 690 | 1 | 0 | |a PASIREOTIDE |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a RECOMBINANT FOLLITROPIN |
| 690 | 1 | 0 | |a SMAD PROTEIN |
| 690 | 1 | 0 | |a SOMATOSTATIN DERIVATIVE |
| 690 | 1 | 0 | |a ACTH SECRETING CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CARCINOGENESIS |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a CELL TYPE |
| 690 | 1 | 0 | |a CUSHING DISEASE |
| 690 | 1 | 0 | |a DISEASE ASSOCIATION |
| 690 | 1 | 0 | |a DRUG MECHANISM |
| 690 | 1 | 0 | |a DRUG POTENTIATION |
| 690 | 1 | 0 | |a GENETIC TRANSCRIPTION |
| 690 | 1 | 0 | |a GONADOTROPIN SECRETING CELL |
| 690 | 1 | 0 | |a GROWTH HORMONE SECRETING ADENOMA |
| 690 | 1 | 0 | |a HORMONE RELEASE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HYPOPHYSIS ADENOMA |
| 690 | 1 | 0 | |a HYPOPHYSIS TUMOR |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROLACTIN SECRETING CELL |
| 690 | 1 | 0 | |a PROLACTINOMA |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a ADRENOCORTICOTROPIC HORMONE |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEIN 4 |
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEINS |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a PITUITARY ACTH HYPERSECRETION |
| 690 | 1 | 0 | |a PITUITARY GLAND |
| 690 | 1 | 0 | |a PITUITARY NEOPLASMS |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a PROLACTINOMA |
| 690 | 1 | 0 | |a RATS |
| 653 | 0 | 0 | |a som 230 |
| 700 | 1 | |a Páez-Pereda, M. | |
| 700 | 1 | |a Haedo, M. | |
| 700 | 1 | |a Arzt, E. | |
| 700 | 1 | |a Stalla, G.K. | |
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