upregulation controlled study 210 nonhuman 182 priority journal 154 article 144 human 144 Animals 136 protein expression 126 Humans 120 metabolism 116 Article 106 human cell 96 animal cell 94 unclassified drug 88 mouse 84 animal experiment 82 animal 78 messenger RNA 78 down regulation 76 genetics 76 female 74 Female 72 Mice 72 animal tissue 72 gene expression regulation 64 male 64 signal transduction 64 apoptosis 56 animal model 54 Male 50