controlled study metabolism nonhuman 118 Animals 90 animal 88 Article 86 oxidative stress 76 priority journal 66 enzyme activity 64 article 60 unclassified drug 58 human 52 Humans 48 animal cell 46 Oxidative Stress 44 chemistry 44 mouse 44 genetics 42 reactive oxygen metabolite 42 animal experiment 40 drug effects 40 Mice 38 oxidation reduction reaction 36 superoxide dismutase 36 animal tissue 34 drug effect 34 glutathione 34 human cell 34 physiology 34 protein expression 34