human 226 human cell controlled study 198 article 182 enzyme activity 156 Humans 152 priority journal 146 signal transduction 84 enzyme activation 82 protein expression 80 nonhuman 72 unclassified drug 68 Animals 64 Cell Line, Tumor 56 cell proliferation 56 metabolism 56 apoptosis 46 mouse 44 Article 42 Mice 42 animal cell 42 Cell Line 38 Female 38 enzyme inhibition 38 Signal Transduction 36 male 36 mitogen activated protein kinase 36 protein phosphorylation 34 Apoptosis 32 Western blotting 32