article controlled study human human cell priority journal Humans Neutrophils neutrophil Cells, Cultured cell culture bacterial DNA cytokine production interleukin 8 leukocyte activation mitogen activated protein kinase 1 mitogen activated protein kinase 3 mitogen activated protein kinase p38 signal transduction CpG DNA, Bacterial Inflammation NF-kappa B immunoglobulin enhancer binding protein phosphatidylinositol 3 kinase protein expression protein kinase B 2 (2 amino 3 methoxyphenyl)chromone 3 (4 methylphenylsulfonyl) 2 propenenitrile 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole Apoptosis