enzyme activity protein expression 232 nonhuman 200 controlled study 198 article 170 priority journal 170 Animals 134 unclassified drug 94 animal cell 90 mouse 90 animal experiment 86 Mice 70 animal tissue 70 human 68 metabolism 64 Humans 58 signal transduction 56 Article 54 human cell 54 protein function 54 animal model 48 rat 48 male 44 Western blotting 42 cell proliferation 42 Female 40 Rats 40 animal 40 Male 38 female 38