enzyme activity nonhuman article 30 controlled study 28 Animals 22 animal experiment 22 animal tissue 22 5 aminolevulinate synthase 18 aminolevulinic acid 18 heme 18 mouse 18 Mice 16 male 16 Aminolevulinic Acid 14 Animalia 14 Liver 14 animal model 14 Heme 12 Male 12 heme oxygenase 12 oxidative stress 12 priority journal 12 5-Aminolevulinate Synthetase 10 Heme metabolism 10 acute intermittent porphyria 10 allylisopropylacetamide 10 enflurane 10 isoflurane 10 lipid peroxidation 10 liver 10