dose time effect relation nonhuman 34 animal cell 24 priority journal 22 article 20 controlled study 20 animal experiment 18 dose response 18 Animal 16 Animals 16 Dose-Response Relationship, Drug 16 rat 16 Rats 14 Support, Non-U.S. Gov't 14 drug comparison 10 drug mechanism 10 drug response 10 Female 8 Liver 8 Male 8 Mice 8 Rats, Inbred Strains 8 central nervous system 8 in vitro study 8 intraperitoneal drug administration 8 protein synthesis 8 radioisotope 8 unclassified drug 8 5 aminolevulinate synthase 6 Glucose 6