article binding affinity 124 priority journal nonhuman 86 controlled study 68 unclassified drug 54 Animals 48 Humans 40 human 40 Protein Binding 38 Molecular Sequence Data 28 binding site 28 Amino Acid Sequence 26 carboxy terminal sequence 24 protein binding 24 animal cell 22 enzyme activity 22 Binding Sites 20 DNA 20 Kinetics 20 metabolism 20 Male 18 animal tissue 18 rat 18 Rats 16 Trypanosoma cruzi 16 conformational transition 16 human cell 16 male 16 mouse 16