article binding affinity 98 controlled study nonhuman 74 priority journal 68 unclassified drug 48 Animals 46 Humans 30 human 30 binding site 26 enzyme activity 26 Protein Binding 24 Male 20 Molecular Sequence Data 20 Rats 20 animal cell 20 animal tissue 20 human cell 20 protein binding 20 rat 20 in vitro study 18 ligand binding 18 male 18 molecular dynamics 18 conformational transition 16 drug receptor binding 16 Amino Acid Sequence 14 Models, Molecular 14 Rats, Sprague-Dawley 14 complex formation 14